Case Report: MOGAD - a steroid-responsive autoimmune meningoencephalitis mimicking infection
This case series reports three patients initially managed for presumed infectious meningoencephalitis, who were ultimately diagnosed with myelin oligodendrocyte glycoprotein associated disease (MOGAD). Their clinical presentations were strikingly similar to those of acute infectious meningoencephali...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1516178/full |
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| author | Yihui Goh Priscillia Pei Shi Lye Paul Anantharajah Tambyah Paul Anantharajah Tambyah Paul Anantharajah Tambyah Derek Tuck Loong Soon Derek Tuck Loong Soon Nares Smitasin Nares Smitasin Jonathan Jia Yuan Ong Jonathan Jia Yuan Ong Clement Hsiang Rong Yong Clement Hsiang Rong Yong Yee Cheun Chan Yee Cheun Chan David Tang Kay Wei Ping Ng Kay Wei Ping Ng Raymond Chee Seong Seet Raymond Chee Seong Seet Amy May Lin Quek Amy May Lin Quek |
| author_facet | Yihui Goh Priscillia Pei Shi Lye Paul Anantharajah Tambyah Paul Anantharajah Tambyah Paul Anantharajah Tambyah Derek Tuck Loong Soon Derek Tuck Loong Soon Nares Smitasin Nares Smitasin Jonathan Jia Yuan Ong Jonathan Jia Yuan Ong Clement Hsiang Rong Yong Clement Hsiang Rong Yong Yee Cheun Chan Yee Cheun Chan David Tang Kay Wei Ping Ng Kay Wei Ping Ng Raymond Chee Seong Seet Raymond Chee Seong Seet Amy May Lin Quek Amy May Lin Quek |
| author_sort | Yihui Goh |
| collection | DOAJ |
| description | This case series reports three patients initially managed for presumed infectious meningoencephalitis, who were ultimately diagnosed with myelin oligodendrocyte glycoprotein associated disease (MOGAD). Their clinical presentations were strikingly similar to those of acute infectious meningoencephalitis, which posed a challenge to the initial diagnostic process. Notably, despite the absence of typical radiological changes associated with MOGAD, such as cerebral cortical encephalitis, these patients exhibited focal neurological and electroencephalographic changes. This series highlights the importance of considering MOG antibody testing in cases of aseptic meningoencephalitis, where early and accurate diagnosis can influence treatment decisions and patient outcomes in this steroid-responsive condition. |
| format | Article |
| id | doaj-art-b185d3cf6c2e4c689d857be28e8f78aa |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-b185d3cf6c2e4c689d857be28e8f78aa2025-08-20T03:10:53ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-02-011610.3389/fimmu.2025.15161781516178Case Report: MOGAD - a steroid-responsive autoimmune meningoencephalitis mimicking infectionYihui Goh0Priscillia Pei Shi Lye1Paul Anantharajah Tambyah2Paul Anantharajah Tambyah3Paul Anantharajah Tambyah4Derek Tuck Loong Soon5Derek Tuck Loong Soon6Nares Smitasin7Nares Smitasin8Jonathan Jia Yuan Ong9Jonathan Jia Yuan Ong10Clement Hsiang Rong Yong11Clement Hsiang Rong Yong12Yee Cheun Chan13Yee Cheun Chan14David Tang15Kay Wei Ping Ng16Kay Wei Ping Ng17Raymond Chee Seong Seet18Raymond Chee Seong Seet19Amy May Lin Quek20Amy May Lin Quek21Division of Neurology, Department of Medicine, National University Hospital, Singapore, SingaporeDivision of Infectious Diseases, Department of Medicine, National University Hospital, Singapore, SingaporeDivision of Infectious Diseases, Department of Medicine, National University Hospital, Singapore, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeInfectious Diseases Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDivision of Neurology, Department of Medicine, National University Hospital, Singapore, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDivision of Infectious Diseases, Department of Medicine, National University Hospital, Singapore, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDivision of Neurology, Department of Medicine, National University Hospital, Singapore, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDepartment of Diagnostic Imaging, National University Hospital, Singapore, SingaporeDepartment of Diagnostic Imaging, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDivision of Neurology, Department of Medicine, National University Hospital, Singapore, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDivision of Neurology, Department of Medicine, National University Hospital, Singapore, SingaporeDivision of Neurology, Department of Medicine, National University Hospital, Singapore, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDivision of Neurology, Department of Medicine, National University Hospital, Singapore, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDivision of Neurology, Department of Medicine, National University Hospital, Singapore, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeThis case series reports three patients initially managed for presumed infectious meningoencephalitis, who were ultimately diagnosed with myelin oligodendrocyte glycoprotein associated disease (MOGAD). Their clinical presentations were strikingly similar to those of acute infectious meningoencephalitis, which posed a challenge to the initial diagnostic process. Notably, despite the absence of typical radiological changes associated with MOGAD, such as cerebral cortical encephalitis, these patients exhibited focal neurological and electroencephalographic changes. This series highlights the importance of considering MOG antibody testing in cases of aseptic meningoencephalitis, where early and accurate diagnosis can influence treatment decisions and patient outcomes in this steroid-responsive condition.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1516178/fullMOGADMOG-IgGaseptic meningoencephalitiscerebral cortical encephalitisautoimmune |
| spellingShingle | Yihui Goh Priscillia Pei Shi Lye Paul Anantharajah Tambyah Paul Anantharajah Tambyah Paul Anantharajah Tambyah Derek Tuck Loong Soon Derek Tuck Loong Soon Nares Smitasin Nares Smitasin Jonathan Jia Yuan Ong Jonathan Jia Yuan Ong Clement Hsiang Rong Yong Clement Hsiang Rong Yong Yee Cheun Chan Yee Cheun Chan David Tang Kay Wei Ping Ng Kay Wei Ping Ng Raymond Chee Seong Seet Raymond Chee Seong Seet Amy May Lin Quek Amy May Lin Quek Case Report: MOGAD - a steroid-responsive autoimmune meningoencephalitis mimicking infection Frontiers in Immunology MOGAD MOG-IgG aseptic meningoencephalitis cerebral cortical encephalitis autoimmune |
| title | Case Report: MOGAD - a steroid-responsive autoimmune meningoencephalitis mimicking infection |
| title_full | Case Report: MOGAD - a steroid-responsive autoimmune meningoencephalitis mimicking infection |
| title_fullStr | Case Report: MOGAD - a steroid-responsive autoimmune meningoencephalitis mimicking infection |
| title_full_unstemmed | Case Report: MOGAD - a steroid-responsive autoimmune meningoencephalitis mimicking infection |
| title_short | Case Report: MOGAD - a steroid-responsive autoimmune meningoencephalitis mimicking infection |
| title_sort | case report mogad a steroid responsive autoimmune meningoencephalitis mimicking infection |
| topic | MOGAD MOG-IgG aseptic meningoencephalitis cerebral cortical encephalitis autoimmune |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1516178/full |
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