Characterization of uniquely tumorigenic cancer stem cells in salivary gland adenoid cystic carcinoma

Characterization of uniquely tumorigenic cancer stem cells in salivary gland adenoid cystic carcinoma

BackgroundCancer stem cells (CSC) are endowed with multipotency, self-renewal and unique tumorigenic potential. They have been identified as cells with high activity of aldehyde dehydrogenase (ALDH) and high expression of CD44 in head and neck squamous cell carcinoma (HNSCC). The objective of this w...

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Bibliographic Details
Main Authors: Kristy A. Warner, Sosuke Sahara, Alexandra E. Herzog, Felipe Nör, Rogerio M. Castilho, Peter J. Polverini, Jacques E. Nör
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Oral Health
Subjects:
salivary gland cancer
cancer stemness
tumor-initiating cells
aldehyde dehydrogenase
tumor cell heterogeneity
Online Access:https://www.frontiersin.org/articles/10.3389/froh.2025.1570042/full
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