Brain functional alternation in patients with systemic sclerosis: a resting-state functional magnetic resonance imaging study
Abstract Background Neuropsychiatric manifestations, such as cognitive impairment, are relatively prevalent in systemic sclerosis (SSc) patients. This study aimed to investigate the resting state (RS) functional alternations of SSc patients and the potential influenced factors. Methods Forty-four SS...
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BMC
2024-11-01
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| Series: | Arthritis Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13075-024-03433-3 |
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| author | Xinyu Tong Huilin He Shihan Xu Rui Shen Zihan Ning Xiaofeng Zeng Qian Wang Dong Xu Zuo-Xiang He Xihai Zhao |
| author_facet | Xinyu Tong Huilin He Shihan Xu Rui Shen Zihan Ning Xiaofeng Zeng Qian Wang Dong Xu Zuo-Xiang He Xihai Zhao |
| author_sort | Xinyu Tong |
| collection | DOAJ |
| description | Abstract Background Neuropsychiatric manifestations, such as cognitive impairment, are relatively prevalent in systemic sclerosis (SSc) patients. This study aimed to investigate the resting state (RS) functional alternations of SSc patients and the potential influenced factors. Methods Forty-four SSc patients (mean age, 46.3 ± 11.4 years; 40 females) and 19 age and sex comparable healthy volunteers (mean age, 42.6 ± 11.3 years; 16 females) were recruited and underwent RS functional MR imaging (fMRI) and neuropsychological assessments. Functional segregation analysis was performed to calculate the amplitude of low frequency fluctuation (ALFF) and regional homogeneity (ReHo). Functional integration analysis was conducted using group independent component analysis to calculate intra-network and inter-network functional connectivity (FC). The fMRI measurements were compared between SSc patients and healthy volunteers using voxel-based pairwise two-sample t-tests. The correlations between clinical characteristics and fMRI measurements were also analyzed. Results Compared to healthy volunteers, SSc patients exhibited significantly decreased ALFF and increased ReHo (all P < 0.01, FWE corrected). SSc patients predominantly showed decreased intra-network and inter-network FC in the auditory network, visual network, default mode network, frontoparietal network and attention network (intra-network FC: P < 0.01, uncorrected, cluster size > 30; inter-network FC: P < 0.05, FDR correction). Furthermore, clinical characteristics including disease duration (r value ranged from − 0.31 to 0.36), elevated erythrocyte sedimentation rate (r = 0.35), Montreal Cognitive Assessment score (r = 0.43), and Hamilton Depression Scale score (r = -0.40) were significantly associated with fMRI measurements (all P < 0.05). Conclusions Spontaneous activity and functional connectivity alternations can be seen in SSc patients, which are partially associated with neuropsychiatric manifestations and tend to aggravate with disease duration. |
| format | Article |
| id | doaj-art-b181f91cc2c4414f9502e026b23d7d0c |
| institution | DOAJ |
| issn | 1478-6362 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
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| series | Arthritis Research & Therapy |
| spelling | doaj-art-b181f91cc2c4414f9502e026b23d7d0c2025-08-20T02:49:59ZengBMCArthritis Research & Therapy1478-63622024-11-0126111110.1186/s13075-024-03433-3Brain functional alternation in patients with systemic sclerosis: a resting-state functional magnetic resonance imaging studyXinyu Tong0Huilin He1Shihan Xu2Rui Shen3Zihan Ning4Xiaofeng Zeng5Qian Wang6Dong Xu7Zuo-Xiang He8Xihai Zhao9Department of Nuclear Medicine, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua UniversityDepartment of Rheumatology,Peking Union Medical College Hospital,Peking Union Medical College and Chinese Academy of Medical Sciences,National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID),Key Laboratory of Rheumatology & Clinical Immunology, Ministry of EducationDepartment of Rheumatology,Peking Union Medical College Hospital,Peking Union Medical College and Chinese Academy of Medical Sciences,National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID),Key Laboratory of Rheumatology & Clinical Immunology, Ministry of EducationCenter for Biomedical Imaging Research, School of Biomedical Engineering, Tsinghua UniversityCenter for Biomedical Imaging Research, School of Biomedical Engineering, Tsinghua UniversityDepartment of Rheumatology,Peking Union Medical College Hospital,Peking Union Medical College and Chinese Academy of Medical Sciences,National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID),Key Laboratory of Rheumatology & Clinical Immunology, Ministry of EducationDepartment of Rheumatology,Peking Union Medical College Hospital,Peking Union Medical College and Chinese Academy of Medical Sciences,National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID),Key Laboratory of Rheumatology & Clinical Immunology, Ministry of EducationDepartment of Rheumatology,Peking Union Medical College Hospital,Peking Union Medical College and Chinese Academy of Medical Sciences,National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID),Key Laboratory of Rheumatology & Clinical Immunology, Ministry of EducationDepartment of Nuclear Medicine, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua UniversityCenter for Biomedical Imaging Research, School of Biomedical Engineering, Tsinghua UniversityAbstract Background Neuropsychiatric manifestations, such as cognitive impairment, are relatively prevalent in systemic sclerosis (SSc) patients. This study aimed to investigate the resting state (RS) functional alternations of SSc patients and the potential influenced factors. Methods Forty-four SSc patients (mean age, 46.3 ± 11.4 years; 40 females) and 19 age and sex comparable healthy volunteers (mean age, 42.6 ± 11.3 years; 16 females) were recruited and underwent RS functional MR imaging (fMRI) and neuropsychological assessments. Functional segregation analysis was performed to calculate the amplitude of low frequency fluctuation (ALFF) and regional homogeneity (ReHo). Functional integration analysis was conducted using group independent component analysis to calculate intra-network and inter-network functional connectivity (FC). The fMRI measurements were compared between SSc patients and healthy volunteers using voxel-based pairwise two-sample t-tests. The correlations between clinical characteristics and fMRI measurements were also analyzed. Results Compared to healthy volunteers, SSc patients exhibited significantly decreased ALFF and increased ReHo (all P < 0.01, FWE corrected). SSc patients predominantly showed decreased intra-network and inter-network FC in the auditory network, visual network, default mode network, frontoparietal network and attention network (intra-network FC: P < 0.01, uncorrected, cluster size > 30; inter-network FC: P < 0.05, FDR correction). Furthermore, clinical characteristics including disease duration (r value ranged from − 0.31 to 0.36), elevated erythrocyte sedimentation rate (r = 0.35), Montreal Cognitive Assessment score (r = 0.43), and Hamilton Depression Scale score (r = -0.40) were significantly associated with fMRI measurements (all P < 0.05). Conclusions Spontaneous activity and functional connectivity alternations can be seen in SSc patients, which are partially associated with neuropsychiatric manifestations and tend to aggravate with disease duration.https://doi.org/10.1186/s13075-024-03433-3Systemic sclerosisBrainResting state fMRIIndependent component analysis |
| spellingShingle | Xinyu Tong Huilin He Shihan Xu Rui Shen Zihan Ning Xiaofeng Zeng Qian Wang Dong Xu Zuo-Xiang He Xihai Zhao Brain functional alternation in patients with systemic sclerosis: a resting-state functional magnetic resonance imaging study Arthritis Research & Therapy Systemic sclerosis Brain Resting state fMRI Independent component analysis |
| title | Brain functional alternation in patients with systemic sclerosis: a resting-state functional magnetic resonance imaging study |
| title_full | Brain functional alternation in patients with systemic sclerosis: a resting-state functional magnetic resonance imaging study |
| title_fullStr | Brain functional alternation in patients with systemic sclerosis: a resting-state functional magnetic resonance imaging study |
| title_full_unstemmed | Brain functional alternation in patients with systemic sclerosis: a resting-state functional magnetic resonance imaging study |
| title_short | Brain functional alternation in patients with systemic sclerosis: a resting-state functional magnetic resonance imaging study |
| title_sort | brain functional alternation in patients with systemic sclerosis a resting state functional magnetic resonance imaging study |
| topic | Systemic sclerosis Brain Resting state fMRI Independent component analysis |
| url | https://doi.org/10.1186/s13075-024-03433-3 |
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