Systematic Comparison of CRISPR and shRNA Screens to Identify Essential Genes Using a Graph-Based Unsupervised Learning Model

Systematic Comparison of CRISPR and shRNA Screens to Identify Essential Genes Using a Graph-Based Unsupervised Learning Model

Generally, essential genes identified using shRNA and CRISPR are not always the same, raising questions about the choice between these two screening platforms. To address this, we systematically compared the performance of CRISPR and shRNA to identify essential genes across different gene expression...

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Bibliographic Details
Main Authors: Yulian Ding, Connor Denomy, Andrew Freywald, Yi Pan, Franco J. Vizeacoumar, Frederick S. Vizeacoumar, Fang-Xiang Wu
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Cells
Subjects:
CRISPR
shRNA
gene expression
essential gene
graph-based model
consensus maximization
Online Access:https://www.mdpi.com/2073-4409/13/19/1653
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