Diagnostic accuracy evaluation of individual or combinational fecal immunochemical test, M3 gene, KRAS mutation and tumor methylation burden in colorectal carcinoma

Diagnostic accuracy evaluation of individual or combinational fecal immunochemical test, M3 gene, KRAS mutation and tumor methylation burden in colorectal carcinoma

ObjectiveThis study is aimed to develop multivariate prediction method in colorectal cancer (CRC) diagnosis.MethodologyM3 gene expression was determined using Fecal DNA extraction kits and performed by qRT-PCR. Methylation-burden and KRAS-mutation were detected by using the corresponding kits. Recei...

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Bibliographic Details
Main Authors: Junyue Xu, Shuai Chen, Hongxia Niu, Yahong Zhao, Xiaohong Wu, Yi Li, Shana Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
colorectal carcinoma
fecal immunochemical test
M3
KRAS mutation
tumor methylation burden
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1627130/full
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