A Retrospective Study on Amoxicillin Susceptibility in Severe Haemophilus influenzae Pneumonia

Introduction. Treatment of Haemophilus influenzae (Hi) pneumonia is on concern because resistance to amoxicillin is largely diffused. This study describes the evolution of resistance to amoxicillin and amoxicillin/clavulanic acid (AMC) in Hi isolates and characteristics of patients with Hi severe pn...

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Main Authors: Pierre Danneels, Maria Concetta Postorino, Alessio Strazzulla, Nabil Belfeki, Aurelia Pitch, Frank Pourcine, Sebastien Jochmans, Vincent Dubée, Mehran Monchi, Sylvain Diamantis
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Canadian Journal of Infectious Diseases and Medical Microbiology
Online Access:http://dx.doi.org/10.1155/2020/2093468
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author Pierre Danneels
Maria Concetta Postorino
Alessio Strazzulla
Nabil Belfeki
Aurelia Pitch
Frank Pourcine
Sebastien Jochmans
Vincent Dubée
Mehran Monchi
Sylvain Diamantis
author_facet Pierre Danneels
Maria Concetta Postorino
Alessio Strazzulla
Nabil Belfeki
Aurelia Pitch
Frank Pourcine
Sebastien Jochmans
Vincent Dubée
Mehran Monchi
Sylvain Diamantis
author_sort Pierre Danneels
collection DOAJ
description Introduction. Treatment of Haemophilus influenzae (Hi) pneumonia is on concern because resistance to amoxicillin is largely diffused. This study describes the evolution of resistance to amoxicillin and amoxicillin/clavulanic acid (AMC) in Hi isolates and characteristics of patients with Hi severe pneumonia. Methods. A monocentric retrospective observational study including patients from 2008 to 2017 with severe pneumonia hospitalized in ICU. Evolution of amoxicillin and AMC susceptibility was showed. Characteristics of patients with Hi pneumonia were compared to characteristics of patients with Streptococcus pneumoniae (Sp) pneumonia, as reference. Risk factors for amoxicillin resistance in Hi were investigated. Results. Overall, 113 patients with Hi and 132 with Sp pneumonia were included. The percentages of AMC resistance among Hi strains decreased over the years (from 10% in 2008-2009 to 0% in 2016-2017) while resistance to amoxicillin remained stable at 20%. Also, percentages of Sp resistant strains for amoxicillin decreased over years (from 25% to 3%). Patients with Hi pneumonia experienced higher prevalence of bronchitis (18% vs. 8%, p=0.02, chronic obstructive pulmonary disease (43% vs. 30% p=0.03), HAP (18% vs. 7%, p=0.01, ventilator-associated pneumonia (27% vs. 17%, p=0.04, and longer duration of mechanical ventilation (8 days vs. 6 days, p=0.04) than patients with Sp pneumonia. Patients with Sp pneumonia had more frequently local complications than patients with Hi pneumonia (17% vs. 7%, p=0.03). De-escalation of antibiotics was more frequent in patients with Sp than in patients with Hi (67% vs. 53%, p=0.03). No risk factors were associated with amoxicillin resistance among patients with Hi pneumonia. Conclusions. Amoxicillin resistance was stable over time, but no risk factors were detected. AMC resistance was extremely low, suggesting that AMC could be used for empiric treatment of Hi pneumonia, as well as other molecules, namely, cephalosporins. Patients with Hi pneumonia had more pulmonary comorbidities and severe diseases than patients with Sp pneumonia.
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spelling doaj-art-b17b7d29382b45ec8df4c84170a81e5f2025-02-03T01:28:32ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932020-01-01202010.1155/2020/20934682093468A Retrospective Study on Amoxicillin Susceptibility in Severe Haemophilus influenzae PneumoniaPierre Danneels0Maria Concetta Postorino1Alessio Strazzulla2Nabil Belfeki3Aurelia Pitch4Frank Pourcine5Sebastien Jochmans6Vincent Dubée7Mehran Monchi8Sylvain Diamantis9Infectious Diseases Unit, Groupe Hospitalier Sud Ile de France, Melun, FranceInfectious Diseases Unit, Groupe Hospitalier Sud Ile de France, Melun, FranceInfectious Diseases Unit, Groupe Hospitalier Sud Ile de France, Melun, FranceInternal Medicine Unit, Groupe Hospitalier Sud Ile de France, Melun, FranceMedical Biology Laboratory, Groupe Hospitalier Sud Ile de France, Melun, FranceIntensive Care Unit, Groupe Hospitalier Sud Ile de France, Melun, FranceIntensive Care Unit, Groupe Hospitalier Sud Ile de France, Melun, FranceCRCINA, Inserm, Paris, FranceIntensive Care Unit, Groupe Hospitalier Sud Ile de France, Melun, FranceInfectious Diseases Unit, Groupe Hospitalier Sud Ile de France, Melun, FranceIntroduction. Treatment of Haemophilus influenzae (Hi) pneumonia is on concern because resistance to amoxicillin is largely diffused. This study describes the evolution of resistance to amoxicillin and amoxicillin/clavulanic acid (AMC) in Hi isolates and characteristics of patients with Hi severe pneumonia. Methods. A monocentric retrospective observational study including patients from 2008 to 2017 with severe pneumonia hospitalized in ICU. Evolution of amoxicillin and AMC susceptibility was showed. Characteristics of patients with Hi pneumonia were compared to characteristics of patients with Streptococcus pneumoniae (Sp) pneumonia, as reference. Risk factors for amoxicillin resistance in Hi were investigated. Results. Overall, 113 patients with Hi and 132 with Sp pneumonia were included. The percentages of AMC resistance among Hi strains decreased over the years (from 10% in 2008-2009 to 0% in 2016-2017) while resistance to amoxicillin remained stable at 20%. Also, percentages of Sp resistant strains for amoxicillin decreased over years (from 25% to 3%). Patients with Hi pneumonia experienced higher prevalence of bronchitis (18% vs. 8%, p=0.02, chronic obstructive pulmonary disease (43% vs. 30% p=0.03), HAP (18% vs. 7%, p=0.01, ventilator-associated pneumonia (27% vs. 17%, p=0.04, and longer duration of mechanical ventilation (8 days vs. 6 days, p=0.04) than patients with Sp pneumonia. Patients with Sp pneumonia had more frequently local complications than patients with Hi pneumonia (17% vs. 7%, p=0.03). De-escalation of antibiotics was more frequent in patients with Sp than in patients with Hi (67% vs. 53%, p=0.03). No risk factors were associated with amoxicillin resistance among patients with Hi pneumonia. Conclusions. Amoxicillin resistance was stable over time, but no risk factors were detected. AMC resistance was extremely low, suggesting that AMC could be used for empiric treatment of Hi pneumonia, as well as other molecules, namely, cephalosporins. Patients with Hi pneumonia had more pulmonary comorbidities and severe diseases than patients with Sp pneumonia.http://dx.doi.org/10.1155/2020/2093468
spellingShingle Pierre Danneels
Maria Concetta Postorino
Alessio Strazzulla
Nabil Belfeki
Aurelia Pitch
Frank Pourcine
Sebastien Jochmans
Vincent Dubée
Mehran Monchi
Sylvain Diamantis
A Retrospective Study on Amoxicillin Susceptibility in Severe Haemophilus influenzae Pneumonia
Canadian Journal of Infectious Diseases and Medical Microbiology
title A Retrospective Study on Amoxicillin Susceptibility in Severe Haemophilus influenzae Pneumonia
title_full A Retrospective Study on Amoxicillin Susceptibility in Severe Haemophilus influenzae Pneumonia
title_fullStr A Retrospective Study on Amoxicillin Susceptibility in Severe Haemophilus influenzae Pneumonia
title_full_unstemmed A Retrospective Study on Amoxicillin Susceptibility in Severe Haemophilus influenzae Pneumonia
title_short A Retrospective Study on Amoxicillin Susceptibility in Severe Haemophilus influenzae Pneumonia
title_sort retrospective study on amoxicillin susceptibility in severe haemophilus influenzae pneumonia
url http://dx.doi.org/10.1155/2020/2093468
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