Reduced mesencephalic astrocyte–derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

Reduced mesencephalic astrocyte–derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene, which encodes a ligand-dependent transcription factor. The mutant androgen receptor protein, characterized by polyglutamine expansion, is prone to misfolding...

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Bibliographic Details
Main Authors: Yiyang Qin, Wenzhen Zhu, Tingting Guo, Yiran Zhang, Tingting Xing, Peng Yin, Shihua Li, Xiao-Jiang Li, Su Yang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-09-01
Series:Neural Regeneration Research
Subjects:
androgen receptor
mesencephalic astrocyte-derived neurotrophic factor
mouse model
neurodegeneration
neuronal loss
neurotrophic factor
polyglutamine disease
protein misfolding
spinal and bulbar muscular atrophy
transcription factor
Online Access:https://journals.lww.com/10.4103/NRR.NRR-D-23-01666
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