A Review on Optical Biosensors for Monitoring of Uric Acid and Blood Glucose Using Portable POCT Devices: Status, Challenges, and Future Horizons
The growing demand for real-time, non-invasive, and cost-effective health monitoring has driven significant advancements in portable point-of-care testing (POCT) devices. Among these, optical biosensors have emerged as promising tools for the detection of critical biomarkers such as uric acid (UA) a...
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MDPI AG
2025-03-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/15/4/222 |
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| author | Kermue Vasco Jarnda Heng Dai Anwar Ali Prince L. Bestman Joanna Trafialek Garmai Prosperity Roberts-Jarnda Richmond Anaman Mohamed Gbanda Kamara Pian Wu Ping Ding |
| author_facet | Kermue Vasco Jarnda Heng Dai Anwar Ali Prince L. Bestman Joanna Trafialek Garmai Prosperity Roberts-Jarnda Richmond Anaman Mohamed Gbanda Kamara Pian Wu Ping Ding |
| author_sort | Kermue Vasco Jarnda |
| collection | DOAJ |
| description | The growing demand for real-time, non-invasive, and cost-effective health monitoring has driven significant advancements in portable point-of-care testing (POCT) devices. Among these, optical biosensors have emerged as promising tools for the detection of critical biomarkers such as uric acid (UA) and blood glucose. Different optical transduction methods, like fluorescence, surface plasmon resonance (SPR), and colorimetric approaches, are talked about, with a focus on how sensitive, specific, and portable they are. Despite considerable advancements, several challenges persist, including sensor stability, miniaturization, interference effects, and the need for calibration-free operation. This review also explores issues related to cost-effectiveness, data integration, and wireless connectivity for remote monitoring. The review further examines regulatory considerations and commercialization aspects of optical biosensors, addressing the gap between research developments and clinical implementation. Future perspectives emphasize the integration of artificial intelligence (AI) and healthcare for improved diagnostics, alongside the development of wearable and implantable biosensors for continuous monitoring. Innovative optical biosensors have the potential to change the way people manage their health by quickly and accurately measuring uric acid and glucose levels. This is especially true as the need for decentralized healthcare solutions grows. By critically evaluating existing work and exploring the limitations and opportunities in the field, this review will help guide the development of more efficient, accessible, and reliable POCT devices that can improve patient outcomes and quality of life. |
| format | Article |
| id | doaj-art-b179a53e81ae4cdbbf5e47fb8aa95c34 |
| institution | DOAJ |
| issn | 2079-6374 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj-art-b179a53e81ae4cdbbf5e47fb8aa95c342025-08-20T03:14:20ZengMDPI AGBiosensors2079-63742025-03-0115422210.3390/bios15040222A Review on Optical Biosensors for Monitoring of Uric Acid and Blood Glucose Using Portable POCT Devices: Status, Challenges, and Future HorizonsKermue Vasco Jarnda0Heng Dai1Anwar Ali2Prince L. Bestman3Joanna Trafialek4Garmai Prosperity Roberts-Jarnda5Richmond Anaman6Mohamed Gbanda Kamara7Pian Wu8Ping Ding9Xiangya School of Public Health, Central South University, Changsha 410078, ChinaXiangya School of Public Health, Central South University, Changsha 410078, ChinaInstitute of Human Nutrition Sciences, Warsaw University of Life Sciences SGGW, Nowoursynowska 159 St., 02776 Warsaw, PolandXiangya School of Public Health, Central South University, Changsha 410078, ChinaInstitute of Human Nutrition Sciences, Warsaw University of Life Sciences SGGW, Nowoursynowska 159 St., 02776 Warsaw, PolandXiangya School of Nursing, Central South University, Changsha 410078, ChinaSchool of Metallurgy and Environment, Central South University, Changsha 410083, ChinaXiangya School of Public Health, Central South University, Changsha 410078, ChinaXiangya School of Public Health, Central South University, Changsha 410078, ChinaXiangya School of Public Health, Central South University, Changsha 410078, ChinaThe growing demand for real-time, non-invasive, and cost-effective health monitoring has driven significant advancements in portable point-of-care testing (POCT) devices. Among these, optical biosensors have emerged as promising tools for the detection of critical biomarkers such as uric acid (UA) and blood glucose. Different optical transduction methods, like fluorescence, surface plasmon resonance (SPR), and colorimetric approaches, are talked about, with a focus on how sensitive, specific, and portable they are. Despite considerable advancements, several challenges persist, including sensor stability, miniaturization, interference effects, and the need for calibration-free operation. This review also explores issues related to cost-effectiveness, data integration, and wireless connectivity for remote monitoring. The review further examines regulatory considerations and commercialization aspects of optical biosensors, addressing the gap between research developments and clinical implementation. Future perspectives emphasize the integration of artificial intelligence (AI) and healthcare for improved diagnostics, alongside the development of wearable and implantable biosensors for continuous monitoring. Innovative optical biosensors have the potential to change the way people manage their health by quickly and accurately measuring uric acid and glucose levels. This is especially true as the need for decentralized healthcare solutions grows. By critically evaluating existing work and exploring the limitations and opportunities in the field, this review will help guide the development of more efficient, accessible, and reliable POCT devices that can improve patient outcomes and quality of life.https://www.mdpi.com/2079-6374/15/4/222μPADsoptical biosensorsuric acidblood glucose |
| spellingShingle | Kermue Vasco Jarnda Heng Dai Anwar Ali Prince L. Bestman Joanna Trafialek Garmai Prosperity Roberts-Jarnda Richmond Anaman Mohamed Gbanda Kamara Pian Wu Ping Ding A Review on Optical Biosensors for Monitoring of Uric Acid and Blood Glucose Using Portable POCT Devices: Status, Challenges, and Future Horizons Biosensors μPADs optical biosensors uric acid blood glucose |
| title | A Review on Optical Biosensors for Monitoring of Uric Acid and Blood Glucose Using Portable POCT Devices: Status, Challenges, and Future Horizons |
| title_full | A Review on Optical Biosensors for Monitoring of Uric Acid and Blood Glucose Using Portable POCT Devices: Status, Challenges, and Future Horizons |
| title_fullStr | A Review on Optical Biosensors for Monitoring of Uric Acid and Blood Glucose Using Portable POCT Devices: Status, Challenges, and Future Horizons |
| title_full_unstemmed | A Review on Optical Biosensors for Monitoring of Uric Acid and Blood Glucose Using Portable POCT Devices: Status, Challenges, and Future Horizons |
| title_short | A Review on Optical Biosensors for Monitoring of Uric Acid and Blood Glucose Using Portable POCT Devices: Status, Challenges, and Future Horizons |
| title_sort | review on optical biosensors for monitoring of uric acid and blood glucose using portable poct devices status challenges and future horizons |
| topic | μPADs optical biosensors uric acid blood glucose |
| url | https://www.mdpi.com/2079-6374/15/4/222 |
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