Nrf2/cyclooxygenase 2 signaling in Cr(VI)-induced carcinogenesis

Nrf2/cyclooxygenase 2 signaling in Cr(VI)-induced carcinogenesis

Long-term exposure to hexavalent chromium [Cr(VI)] has been linked to lung cancer, and cyclooxygenase-2 (COX-2) is a well-known inflammatory factor. However, the role and mechanism of COX-2 in Cr(VI)-induced carcinogenesis are not clear yet. To address this question, we employed a mouse model expose...

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Bibliographic Details
Main Authors: Lei Zhao, Yi-Fang Wang, Andrea Adamcakova-Dodd, Peter S. Thorne, Ranakul Islam, Ke Jian Liu, Fei Chen, Jia Luo, Ling-Zhi Liu
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Cr(VI)
Carcinogenesis
Nrf2
COX-2
miR-379
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325001368
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