PIDOTIMOD IN TREATMENT OF CHILDREN WITH ACUTE RESPIRATORY INFECTION WITH CONCOMITANT RECURRENT OBSTRUCTIVE SYNDROME
Respiratory infections are frequent in children; consequently evaluation of prophylactic effectiveness of immunomodulators is needed. Objective: to evaluate of clinical, immunological efficacy and safety of pidotimod in complex treatment of children with acute respiratory infections (ARI) and obstru...
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2011-01-01
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| Series: | Вопросы современной педиатрии |
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| Online Access: | https://vsp.spr-journal.ru/jour/article/view/537 |
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| _version_ | 1849242297644875776 |
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| author | E. E. Lokshina O. V. Kravchenko O. V. Zaytseva |
| author_facet | E. E. Lokshina O. V. Kravchenko O. V. Zaytseva |
| author_sort | E. E. Lokshina |
| collection | DOAJ |
| description | Respiratory infections are frequent in children; consequently evaluation of prophylactic effectiveness of immunomodulators is needed. Objective: to evaluate of clinical, immunological efficacy and safety of pidotimod in complex treatment of children with acute respiratory infections (ARI) and obstructive syndrome. Methods: patients 3–10 years old hospitalized with ARI and obstructive syndrome participated the study. Children from first group (n = 30) were treated with pidotimod 400 mg 2 times daily during 14 days, children from control group (n = 30) received standard treatment without immunomodulatory agent. Dynamics of clinical course of a disease, immunological indices of blood (IL 2, 4 and 8, interferon α and γ, IgA, M, G and total IgЕ) and swabs from mucous tunica of nasopharynx (sIgA) was estimated. The cases of recurrent ARIs during 12 months after the beginning of a study were controlled. Results: treatment with pidotimod induced statistically significant decrease of cytokines levels (IL 2, IL 8, and interferon γ) and increase of sIgA. The rate of recurrent ARIs during 12 months after the beginning of a study was lower than in control group. Recurrent episodes of bronchial obstruction occurred rarely. Conclusion: pidotimod has high clinical and immunological effectiveness and safety in treatment of children with ARI and concomitant obstructive syndrome. |
| format | Article |
| id | doaj-art-b1778bcb5c884662b99b25dd9c3de5a2 |
| institution | Kabale University |
| issn | 1682-5527 1682-5535 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj-art-b1778bcb5c884662b99b25dd9c3de5a22025-08-20T03:59:52Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352011-01-011013441537PIDOTIMOD IN TREATMENT OF CHILDREN WITH ACUTE RESPIRATORY INFECTION WITH CONCOMITANT RECURRENT OBSTRUCTIVE SYNDROMEE. E. Lokshina0O. V. Kravchenko1O. V. Zaytseva2Moscow State University of Medicine and DentistryMoscow State University of Medicine and DentistryMoscow State University of Medicine and DentistryRespiratory infections are frequent in children; consequently evaluation of prophylactic effectiveness of immunomodulators is needed. Objective: to evaluate of clinical, immunological efficacy and safety of pidotimod in complex treatment of children with acute respiratory infections (ARI) and obstructive syndrome. Methods: patients 3–10 years old hospitalized with ARI and obstructive syndrome participated the study. Children from first group (n = 30) were treated with pidotimod 400 mg 2 times daily during 14 days, children from control group (n = 30) received standard treatment without immunomodulatory agent. Dynamics of clinical course of a disease, immunological indices of blood (IL 2, 4 and 8, interferon α and γ, IgA, M, G and total IgЕ) and swabs from mucous tunica of nasopharynx (sIgA) was estimated. The cases of recurrent ARIs during 12 months after the beginning of a study were controlled. Results: treatment with pidotimod induced statistically significant decrease of cytokines levels (IL 2, IL 8, and interferon γ) and increase of sIgA. The rate of recurrent ARIs during 12 months after the beginning of a study was lower than in control group. Recurrent episodes of bronchial obstruction occurred rarely. Conclusion: pidotimod has high clinical and immunological effectiveness and safety in treatment of children with ARI and concomitant obstructive syndrome.https://vsp.spr-journal.ru/jour/article/view/537childrenacute respiratory infectionsobstructive syndromepidotimodtreatment |
| spellingShingle | E. E. Lokshina O. V. Kravchenko O. V. Zaytseva PIDOTIMOD IN TREATMENT OF CHILDREN WITH ACUTE RESPIRATORY INFECTION WITH CONCOMITANT RECURRENT OBSTRUCTIVE SYNDROME Вопросы современной педиатрии children acute respiratory infections obstructive syndrome pidotimod treatment |
| title | PIDOTIMOD IN TREATMENT OF CHILDREN WITH ACUTE RESPIRATORY INFECTION WITH CONCOMITANT RECURRENT OBSTRUCTIVE SYNDROME |
| title_full | PIDOTIMOD IN TREATMENT OF CHILDREN WITH ACUTE RESPIRATORY INFECTION WITH CONCOMITANT RECURRENT OBSTRUCTIVE SYNDROME |
| title_fullStr | PIDOTIMOD IN TREATMENT OF CHILDREN WITH ACUTE RESPIRATORY INFECTION WITH CONCOMITANT RECURRENT OBSTRUCTIVE SYNDROME |
| title_full_unstemmed | PIDOTIMOD IN TREATMENT OF CHILDREN WITH ACUTE RESPIRATORY INFECTION WITH CONCOMITANT RECURRENT OBSTRUCTIVE SYNDROME |
| title_short | PIDOTIMOD IN TREATMENT OF CHILDREN WITH ACUTE RESPIRATORY INFECTION WITH CONCOMITANT RECURRENT OBSTRUCTIVE SYNDROME |
| title_sort | pidotimod in treatment of children with acute respiratory infection with concomitant recurrent obstructive syndrome |
| topic | children acute respiratory infections obstructive syndrome pidotimod treatment |
| url | https://vsp.spr-journal.ru/jour/article/view/537 |
| work_keys_str_mv | AT eelokshina pidotimodintreatmentofchildrenwithacuterespiratoryinfectionwithconcomitantrecurrentobstructivesyndrome AT ovkravchenko pidotimodintreatmentofchildrenwithacuterespiratoryinfectionwithconcomitantrecurrentobstructivesyndrome AT ovzaytseva pidotimodintreatmentofchildrenwithacuterespiratoryinfectionwithconcomitantrecurrentobstructivesyndrome |