Isoform-specific roles of AMP-activated protein kinase in cardiac physiology and pathophysiology

Isoform-specific roles of AMP-activated protein kinase in cardiac physiology and pathophysiology

AMP-activated protein kinase (AMPK) is a central regulator of cellular energy homeostasis, integrating metabolic, mitochondrial, and oxidative stress responses. In the heart, an organ with high and dynamically fluctuating energy demands, AMPK is essential for maintaining metabolic balance, particula...

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Bibliographic Details
Main Authors: Ani Rakoubian, Julia Khinchin, Johnathan Yarbro, Satoru Kobayashi, Qiangrong Liang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
AMPK
isoform-specific
energy metabolism
mitochondria quality control
cardiac remodeling
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2025.1638515/full
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