Isoform-specific roles of AMP-activated protein kinase in cardiac physiology and pathophysiology
AMP-activated protein kinase (AMPK) is a central regulator of cellular energy homeostasis, integrating metabolic, mitochondrial, and oxidative stress responses. In the heart, an organ with high and dynamically fluctuating energy demands, AMPK is essential for maintaining metabolic balance, particula...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1638515/full |
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| author | Ani Rakoubian Julia Khinchin Johnathan Yarbro Satoru Kobayashi Qiangrong Liang |
| author_facet | Ani Rakoubian Julia Khinchin Johnathan Yarbro Satoru Kobayashi Qiangrong Liang |
| author_sort | Ani Rakoubian |
| collection | DOAJ |
| description | AMP-activated protein kinase (AMPK) is a central regulator of cellular energy homeostasis, integrating metabolic, mitochondrial, and oxidative stress responses. In the heart, an organ with high and dynamically fluctuating energy demands, AMPK is essential for maintaining metabolic balance, particularly during conditions such as exercise, ischemia, hypertrophy, and heart failure. The AMPK complex comprises a catalytic α subunit and regulatory β and γ subunits, each with multiple isoforms (α1, α2; β1, β2; γ1, γ2, γ3) that confer tissue-specific distribution and functional specialization. This review highlights the isoform-specific roles of AMPK in the heart, emphasizing their distinct contributions to myocardial energy metabolism, contractile function, and cardiac remodeling across diverse physiological and pathological conditions. |
| format | Article |
| id | doaj-art-b1773bf22be34b6db60db174d7ba86bc |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-b1773bf22be34b6db60db174d7ba86bc2025-08-20T03:38:55ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-08-011210.3389/fcvm.2025.16385151638515Isoform-specific roles of AMP-activated protein kinase in cardiac physiology and pathophysiologyAni RakoubianJulia KhinchinJohnathan YarbroSatoru KobayashiQiangrong LiangAMP-activated protein kinase (AMPK) is a central regulator of cellular energy homeostasis, integrating metabolic, mitochondrial, and oxidative stress responses. In the heart, an organ with high and dynamically fluctuating energy demands, AMPK is essential for maintaining metabolic balance, particularly during conditions such as exercise, ischemia, hypertrophy, and heart failure. The AMPK complex comprises a catalytic α subunit and regulatory β and γ subunits, each with multiple isoforms (α1, α2; β1, β2; γ1, γ2, γ3) that confer tissue-specific distribution and functional specialization. This review highlights the isoform-specific roles of AMPK in the heart, emphasizing their distinct contributions to myocardial energy metabolism, contractile function, and cardiac remodeling across diverse physiological and pathological conditions.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1638515/fullAMPKisoform-specificenergy metabolismmitochondria quality controlcardiac remodeling |
| spellingShingle | Ani Rakoubian Julia Khinchin Johnathan Yarbro Satoru Kobayashi Qiangrong Liang Isoform-specific roles of AMP-activated protein kinase in cardiac physiology and pathophysiology Frontiers in Cardiovascular Medicine AMPK isoform-specific energy metabolism mitochondria quality control cardiac remodeling |
| title | Isoform-specific roles of AMP-activated protein kinase in cardiac physiology and pathophysiology |
| title_full | Isoform-specific roles of AMP-activated protein kinase in cardiac physiology and pathophysiology |
| title_fullStr | Isoform-specific roles of AMP-activated protein kinase in cardiac physiology and pathophysiology |
| title_full_unstemmed | Isoform-specific roles of AMP-activated protein kinase in cardiac physiology and pathophysiology |
| title_short | Isoform-specific roles of AMP-activated protein kinase in cardiac physiology and pathophysiology |
| title_sort | isoform specific roles of amp activated protein kinase in cardiac physiology and pathophysiology |
| topic | AMPK isoform-specific energy metabolism mitochondria quality control cardiac remodeling |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1638515/full |
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