Design and construction of a fast synthetic modified vaccinia virus Ankara reverse genetics system for advancing vaccine development

The modified vaccinia virus Ankara (MVA) is approved for use as a smallpox and monkeypox virus vaccine and was also designed as a popular recombinant viral vector for vaccine development and gene therapy. However, the extensive genomes of poxviruses present a significant challenge for the developmen...

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Bibliographic Details
Main Authors: Zhiqiang Gao, Busen Wang, Tianyu Liu, Zhenghao Zhao, Jinghan Xu, Xiaofan Zhao, Zhe Zhang, Zuyuan Jia, Yilong Yang, Shipo Wu, Wei Chen, Lihua Hou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Microbiology
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Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1572706/full
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