Tablet characteristics and pharmacokinetics of orally disintegrating tablets containing coenzyme Q10 granules prepared by different methods
This study aimed to elucidate the characteristics and pharmacokinetics of orally disintegrating tablets (ODTs) containing coenzyme Q10 (CoQ10) granules prepared by spray drying, hot-melting, and wet granulation. The hardness and disintegration times of CoQ10-ODTs containing 5 % crospovidone were 61....
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| Format: | Article |
| Language: | English |
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Sciendo
2023-03-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2023-0007 |
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| _version_ | 1832572831700877312 |
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| author | Kashiwagura Yasuharu Takusagawa Shota Ikematsu Yasuyuki Tanaka Shimako Namiki Noriyuki Uchida Shinya |
| author_facet | Kashiwagura Yasuharu Takusagawa Shota Ikematsu Yasuyuki Tanaka Shimako Namiki Noriyuki Uchida Shinya |
| author_sort | Kashiwagura Yasuharu |
| collection | DOAJ |
| description | This study aimed to elucidate the characteristics and pharmacokinetics of orally disintegrating tablets (ODTs) containing coenzyme Q10 (CoQ10) granules prepared by spray drying, hot-melting, and wet granulation. The hardness and disintegration times of CoQ10-ODTs containing 5 % crospovidone were 61.6–81.8 N and < 30 s, respectively; these values indicate that the as-prepared ODTs were adequate for clinical use. The hardness and disintegration times of all ODTs did not change significantly after a 28-day storage period at 30 °C/10 % relative humidity (RH), but storage under high temperature and humidity affected their characteristics. The dissolution and pharmacokinetics of CoQ10-ODTs showed that ODTs prepared using the spray-drying method had the highest dissolution and absorbability among the CoQ10-ODTs tested. These results provide useful information for the preparation of ODTs using CoQ10. |
| format | Article |
| id | doaj-art-b175806bb1b8443cb91161527dc59660 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-b175806bb1b8443cb91161527dc596602025-02-02T07:31:15ZengSciendoActa Pharmaceutica1846-95582023-03-0173110711910.2478/acph-2023-0007Tablet characteristics and pharmacokinetics of orally disintegrating tablets containing coenzyme Q10 granules prepared by different methodsKashiwagura Yasuharu0Takusagawa Shota1Ikematsu Yasuyuki2Tanaka Shimako3Namiki Noriyuki4Uchida Shinya5Department of Pharmacy Practice and Science, School of Pharmaceutical Sciences University of Shizuoka; 52–1 Yada Suruga-ku, Shizuoka 422–8526, JapanDepartment of Pharmacy Practice and Science, School of Pharmaceutical Sciences University of Shizuoka; 52–1 Yada Suruga-ku, Shizuoka 422–8526, JapanDepartment of Pharmacy Practice and Science, School of Pharmaceutical Sciences University of Shizuoka; 52–1 Yada Suruga-ku, Shizuoka 422–8526, JapanDepartment of Pharmacy Practice and Science, School of Pharmaceutical Sciences University of Shizuoka; 52–1 Yada Suruga-ku, Shizuoka 422–8526, JapanDepartment of Pharmacy Practice and Science, School of Pharmaceutical Sciences University of Shizuoka; 52–1 Yada Suruga-ku, Shizuoka 422–8526, JapanDepartment of Pharmacy Practice and Science, School of Pharmaceutical Sciences University of Shizuoka; 52–1 Yada Suruga-ku, Shizuoka 422–8526, JapanThis study aimed to elucidate the characteristics and pharmacokinetics of orally disintegrating tablets (ODTs) containing coenzyme Q10 (CoQ10) granules prepared by spray drying, hot-melting, and wet granulation. The hardness and disintegration times of CoQ10-ODTs containing 5 % crospovidone were 61.6–81.8 N and < 30 s, respectively; these values indicate that the as-prepared ODTs were adequate for clinical use. The hardness and disintegration times of all ODTs did not change significantly after a 28-day storage period at 30 °C/10 % relative humidity (RH), but storage under high temperature and humidity affected their characteristics. The dissolution and pharmacokinetics of CoQ10-ODTs showed that ODTs prepared using the spray-drying method had the highest dissolution and absorbability among the CoQ10-ODTs tested. These results provide useful information for the preparation of ODTs using CoQ10.https://doi.org/10.2478/acph-2023-0007coenzyme q10orally disintegrating tabletsgranulesspray dryingtablet characteristicspharmacokinetics |
| spellingShingle | Kashiwagura Yasuharu Takusagawa Shota Ikematsu Yasuyuki Tanaka Shimako Namiki Noriyuki Uchida Shinya Tablet characteristics and pharmacokinetics of orally disintegrating tablets containing coenzyme Q10 granules prepared by different methods Acta Pharmaceutica coenzyme q10 orally disintegrating tablets granules spray drying tablet characteristics pharmacokinetics |
| title | Tablet characteristics and pharmacokinetics of orally disintegrating tablets containing coenzyme Q10 granules prepared by different methods |
| title_full | Tablet characteristics and pharmacokinetics of orally disintegrating tablets containing coenzyme Q10 granules prepared by different methods |
| title_fullStr | Tablet characteristics and pharmacokinetics of orally disintegrating tablets containing coenzyme Q10 granules prepared by different methods |
| title_full_unstemmed | Tablet characteristics and pharmacokinetics of orally disintegrating tablets containing coenzyme Q10 granules prepared by different methods |
| title_short | Tablet characteristics and pharmacokinetics of orally disintegrating tablets containing coenzyme Q10 granules prepared by different methods |
| title_sort | tablet characteristics and pharmacokinetics of orally disintegrating tablets containing coenzyme q10 granules prepared by different methods |
| topic | coenzyme q10 orally disintegrating tablets granules spray drying tablet characteristics pharmacokinetics |
| url | https://doi.org/10.2478/acph-2023-0007 |
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