Recent Advancements in Understanding the Role and Mechanisms of Angiopoietin-like Proteins in Diabetic Retinopathy
Angiopoietin-like proteins (ANGPTLs) represent a family of secreted glycoproteins that are extensively expressed in vivo and are integral to various pathophysiological processes, including glucose and lipid metabolism, stem cell proliferation, local inflammation, vascular permeability, and angiogene...
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2025-05-01
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| author | Xinling Zhang Dongang Liu Yuting Qiu Ruiyao Hu Shiyu Chen Yue Xu Chenyan Qian Lailing Du Jinghua Yuan Xiaoping Li |
| author_facet | Xinling Zhang Dongang Liu Yuting Qiu Ruiyao Hu Shiyu Chen Yue Xu Chenyan Qian Lailing Du Jinghua Yuan Xiaoping Li |
| author_sort | Xinling Zhang |
| collection | DOAJ |
| description | Angiopoietin-like proteins (ANGPTLs) represent a family of secreted glycoproteins that are extensively expressed in vivo and are integral to various pathophysiological processes, including glucose and lipid metabolism, stem cell proliferation, local inflammation, vascular permeability, and angiogenesis. Particularly interesting is ANGPTL4, which has been identified as a significant factor in the development and progression of diabetic retinopathy (DR), thus becoming a central focus of DR research. ANGPTLs modulate metabolic pathways, enhance vascular permeability, and facilitate pathological angiogenesis, in addition to causing intraocular inflammation. As promising molecular targets, ANGPTLs not only serve as biomarkers for predicting the onset and progression of DR but also present therapeutic potential through antibody-based interventions. This paper discusses the pathogenesis of DR and the potential applications of ANGPTLs in early diagnosis and targeted therapy. It provides references for advancing precision diagnosis and personalized treatment strategies through more profound ANGPTLs research in the future. |
| format | Article |
| id | doaj-art-b171dd99ca2440af8867edef2fad8af2 |
| institution | DOAJ |
| issn | 2218-1989 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj-art-b171dd99ca2440af8867edef2fad8af22025-08-20T03:16:34ZengMDPI AGMetabolites2218-19892025-05-0115635210.3390/metabo15060352Recent Advancements in Understanding the Role and Mechanisms of Angiopoietin-like Proteins in Diabetic RetinopathyXinling Zhang0Dongang Liu1Yuting Qiu2Ruiyao Hu3Shiyu Chen4Yue Xu5Chenyan Qian6Lailing Du7Jinghua Yuan8Xiaoping Li9Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou 310015, ChinaKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou 310015, ChinaKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou 310015, ChinaKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou 310015, ChinaKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou 310015, ChinaKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou 310015, ChinaKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou 310015, ChinaKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou 310015, ChinaKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou 310015, ChinaKey Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou 310015, ChinaAngiopoietin-like proteins (ANGPTLs) represent a family of secreted glycoproteins that are extensively expressed in vivo and are integral to various pathophysiological processes, including glucose and lipid metabolism, stem cell proliferation, local inflammation, vascular permeability, and angiogenesis. Particularly interesting is ANGPTL4, which has been identified as a significant factor in the development and progression of diabetic retinopathy (DR), thus becoming a central focus of DR research. ANGPTLs modulate metabolic pathways, enhance vascular permeability, and facilitate pathological angiogenesis, in addition to causing intraocular inflammation. As promising molecular targets, ANGPTLs not only serve as biomarkers for predicting the onset and progression of DR but also present therapeutic potential through antibody-based interventions. This paper discusses the pathogenesis of DR and the potential applications of ANGPTLs in early diagnosis and targeted therapy. It provides references for advancing precision diagnosis and personalized treatment strategies through more profound ANGPTLs research in the future.https://www.mdpi.com/2218-1989/15/6/352angiopoietin-like proteindiabetic retinopathymolecular mechanismearly diagnosistargeted therapy |
| spellingShingle | Xinling Zhang Dongang Liu Yuting Qiu Ruiyao Hu Shiyu Chen Yue Xu Chenyan Qian Lailing Du Jinghua Yuan Xiaoping Li Recent Advancements in Understanding the Role and Mechanisms of Angiopoietin-like Proteins in Diabetic Retinopathy Metabolites angiopoietin-like protein diabetic retinopathy molecular mechanism early diagnosis targeted therapy |
| title | Recent Advancements in Understanding the Role and Mechanisms of Angiopoietin-like Proteins in Diabetic Retinopathy |
| title_full | Recent Advancements in Understanding the Role and Mechanisms of Angiopoietin-like Proteins in Diabetic Retinopathy |
| title_fullStr | Recent Advancements in Understanding the Role and Mechanisms of Angiopoietin-like Proteins in Diabetic Retinopathy |
| title_full_unstemmed | Recent Advancements in Understanding the Role and Mechanisms of Angiopoietin-like Proteins in Diabetic Retinopathy |
| title_short | Recent Advancements in Understanding the Role and Mechanisms of Angiopoietin-like Proteins in Diabetic Retinopathy |
| title_sort | recent advancements in understanding the role and mechanisms of angiopoietin like proteins in diabetic retinopathy |
| topic | angiopoietin-like protein diabetic retinopathy molecular mechanism early diagnosis targeted therapy |
| url | https://www.mdpi.com/2218-1989/15/6/352 |
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