The gut microbiota-inflammation-HFpEF axis: deciphering the role of gut microbiota dysregulation in the pathogenesis and management of HFpEF
Heart failure with preserved left ventricular ejection fraction (HFpEF) is a disease that affects multiple organs throughout the body, accounting for over 50% of heart failure cases. HFpEF has a significant impact on individuals’ life expectancy and quality of life, but the exact pathogenesis remain...
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| Format: | Article |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1537576/full |
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| author | Shenghua Zhou Xuan Zhou Panpan Zhang Wei Zhang Jinli Huang Xuzhao Jia Xiaole He Xin Sun Hui Su |
| author_facet | Shenghua Zhou Xuan Zhou Panpan Zhang Wei Zhang Jinli Huang Xuzhao Jia Xiaole He Xin Sun Hui Su |
| author_sort | Shenghua Zhou |
| collection | DOAJ |
| description | Heart failure with preserved left ventricular ejection fraction (HFpEF) is a disease that affects multiple organs throughout the body, accounting for over 50% of heart failure cases. HFpEF has a significant impact on individuals’ life expectancy and quality of life, but the exact pathogenesis remains unclear. Emerging evidence implicates low-grade systemic inflammation as a crucial role in the onset and progression of HFpEF. Gut microbiota dysregulation and associated metabolites alteration, including short-chain fatty acids, trimethylamine N-oxides, amino acids, and bile acids can exacerbate chronic systemic inflammatory responses and potentially contribute to HFpEF. In light of these findings, we propose the hypothesis of a “gut microbiota-inflammation-HFpEF axis”, positing that the interplay within this axis could be a crucial factor in the development and progression of HFpEF. This review focuses on the role of gut microbiota dysregulation-induced inflammation in HFpEF’s etiology. It explores the potential mechanisms linking dysregulation of the gut microbiota to cardiac dysfunction and evaluates the therapeutic potential of restoring gut microbiota balance in mitigating HFpEF severity. The objective is to offer novel insights and strategies for the management of HFpEF. |
| format | Article |
| id | doaj-art-b169a648eda94d67b8bd402b4e8ec228 |
| institution | DOAJ |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-b169a648eda94d67b8bd402b4e8ec2282025-08-20T02:52:52ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-03-011510.3389/fcimb.2025.15375761537576The gut microbiota-inflammation-HFpEF axis: deciphering the role of gut microbiota dysregulation in the pathogenesis and management of HFpEFShenghua Zhou0Xuan Zhou1Panpan Zhang2Wei Zhang3Jinli Huang4Xuzhao Jia5Xiaole He6Xin Sun7Hui Su8Department of Geriatrics, Xijing Hospital, the Fourth Military Medical University, Xi’an, ChinaDepartment of Geriatrics, Xijing Hospital, the Fourth Military Medical University, Xi’an, ChinaDepartment of Pediatrics, Xijing Hospital, the Fourth Military Medical University, Xi’an, ChinaDepartment of Pediatrics, Xijing Hospital, the Fourth Military Medical University, Xi’an, ChinaDepartment of Pediatrics, Xijing Hospital, the Fourth Military Medical University, Xi’an, ChinaDepartment of Geriatrics, Xijing Hospital, the Fourth Military Medical University, Xi’an, ChinaDepartment of General Practice, Xijing Hospital, the Fourth Military Medical University, Xi’an, ChinaDepartment of Pediatrics, Xijing Hospital, the Fourth Military Medical University, Xi’an, ChinaDepartment of Geriatrics, Xijing Hospital, the Fourth Military Medical University, Xi’an, ChinaHeart failure with preserved left ventricular ejection fraction (HFpEF) is a disease that affects multiple organs throughout the body, accounting for over 50% of heart failure cases. HFpEF has a significant impact on individuals’ life expectancy and quality of life, but the exact pathogenesis remains unclear. Emerging evidence implicates low-grade systemic inflammation as a crucial role in the onset and progression of HFpEF. Gut microbiota dysregulation and associated metabolites alteration, including short-chain fatty acids, trimethylamine N-oxides, amino acids, and bile acids can exacerbate chronic systemic inflammatory responses and potentially contribute to HFpEF. In light of these findings, we propose the hypothesis of a “gut microbiota-inflammation-HFpEF axis”, positing that the interplay within this axis could be a crucial factor in the development and progression of HFpEF. This review focuses on the role of gut microbiota dysregulation-induced inflammation in HFpEF’s etiology. It explores the potential mechanisms linking dysregulation of the gut microbiota to cardiac dysfunction and evaluates the therapeutic potential of restoring gut microbiota balance in mitigating HFpEF severity. The objective is to offer novel insights and strategies for the management of HFpEF.https://www.frontiersin.org/articles/10.3389/fcimb.2025.1537576/fullHFpEFinflammationgut microbiotametabolitesprobioticsfecal microbial transplantation |
| spellingShingle | Shenghua Zhou Xuan Zhou Panpan Zhang Wei Zhang Jinli Huang Xuzhao Jia Xiaole He Xin Sun Hui Su The gut microbiota-inflammation-HFpEF axis: deciphering the role of gut microbiota dysregulation in the pathogenesis and management of HFpEF Frontiers in Cellular and Infection Microbiology HFpEF inflammation gut microbiota metabolites probiotics fecal microbial transplantation |
| title | The gut microbiota-inflammation-HFpEF axis: deciphering the role of gut microbiota dysregulation in the pathogenesis and management of HFpEF |
| title_full | The gut microbiota-inflammation-HFpEF axis: deciphering the role of gut microbiota dysregulation in the pathogenesis and management of HFpEF |
| title_fullStr | The gut microbiota-inflammation-HFpEF axis: deciphering the role of gut microbiota dysregulation in the pathogenesis and management of HFpEF |
| title_full_unstemmed | The gut microbiota-inflammation-HFpEF axis: deciphering the role of gut microbiota dysregulation in the pathogenesis and management of HFpEF |
| title_short | The gut microbiota-inflammation-HFpEF axis: deciphering the role of gut microbiota dysregulation in the pathogenesis and management of HFpEF |
| title_sort | gut microbiota inflammation hfpef axis deciphering the role of gut microbiota dysregulation in the pathogenesis and management of hfpef |
| topic | HFpEF inflammation gut microbiota metabolites probiotics fecal microbial transplantation |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1537576/full |
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