Shared genetic architecture of gastroesophageal reflux disease and age related phenotypes
Abstract Increasing age is a risk factor of gastroesophageal reflux disease. This study aims to uncover the shared genetic architecture of gastroesophageal reflux disease (GERD) and age-related phenotypes. Based on publicly available GWAS statistics, this genome-wide pleiotropic association research...
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Nature Portfolio
2025-05-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-90943-y |
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| author | Wei Liu Yadan Xiao Manting Zeng |
| author_facet | Wei Liu Yadan Xiao Manting Zeng |
| author_sort | Wei Liu |
| collection | DOAJ |
| description | Abstract Increasing age is a risk factor of gastroesophageal reflux disease. This study aims to uncover the shared genetic architecture of gastroesophageal reflux disease (GERD) and age-related phenotypes. Based on publicly available GWAS statistics, this genome-wide pleiotropic association research was performed with multiple genetic approaches sequentially to explore the pleiotropic associations from single-nucleotide polymorphism (SNP) and gene levels, to reveal the underlying shared genetic etiology between GERD and age-related phenotypes. This study featured shared genetic mechanisms between GERD and age-related phenotypes, including frailty index (FI), telomere length (TL), longevity, and parental lifespan (PL). Strong genetic association were observed. A set of pleiotropic loci and genes were identified by PLACO, FUMA, Bayesian colocalization and additional MAGMA analysis. Our research provided strong evidence of genetic correlation between GERD and several age-related phenotypes, especially frailty index (FI) and telomere length (TL), brought novel insight into the shared genetic architecture between GERD and aging. |
| format | Article |
| id | doaj-art-b169086b2965445ebd644aeb45e73ea2 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-b169086b2965445ebd644aeb45e73ea22025-08-20T01:47:29ZengNature PortfolioScientific Reports2045-23222025-05-011511810.1038/s41598-025-90943-yShared genetic architecture of gastroesophageal reflux disease and age related phenotypesWei Liu0Yadan Xiao1Manting Zeng2Department of Gastrointestinal Surgery, Xiangya Hospital, Central South UniversityDepartment of Anorectal Surgery, Bin hai wan Central Hospital of DongguanDepartment of Oncology, Xiangya Hospital, Central South UniversityAbstract Increasing age is a risk factor of gastroesophageal reflux disease. This study aims to uncover the shared genetic architecture of gastroesophageal reflux disease (GERD) and age-related phenotypes. Based on publicly available GWAS statistics, this genome-wide pleiotropic association research was performed with multiple genetic approaches sequentially to explore the pleiotropic associations from single-nucleotide polymorphism (SNP) and gene levels, to reveal the underlying shared genetic etiology between GERD and age-related phenotypes. This study featured shared genetic mechanisms between GERD and age-related phenotypes, including frailty index (FI), telomere length (TL), longevity, and parental lifespan (PL). Strong genetic association were observed. A set of pleiotropic loci and genes were identified by PLACO, FUMA, Bayesian colocalization and additional MAGMA analysis. Our research provided strong evidence of genetic correlation between GERD and several age-related phenotypes, especially frailty index (FI) and telomere length (TL), brought novel insight into the shared genetic architecture between GERD and aging.https://doi.org/10.1038/s41598-025-90943-yGastroesophageal reflux diseaseAgingGenome-wide pleiotropic association |
| spellingShingle | Wei Liu Yadan Xiao Manting Zeng Shared genetic architecture of gastroesophageal reflux disease and age related phenotypes Scientific Reports Gastroesophageal reflux disease Aging Genome-wide pleiotropic association |
| title | Shared genetic architecture of gastroesophageal reflux disease and age related phenotypes |
| title_full | Shared genetic architecture of gastroesophageal reflux disease and age related phenotypes |
| title_fullStr | Shared genetic architecture of gastroesophageal reflux disease and age related phenotypes |
| title_full_unstemmed | Shared genetic architecture of gastroesophageal reflux disease and age related phenotypes |
| title_short | Shared genetic architecture of gastroesophageal reflux disease and age related phenotypes |
| title_sort | shared genetic architecture of gastroesophageal reflux disease and age related phenotypes |
| topic | Gastroesophageal reflux disease Aging Genome-wide pleiotropic association |
| url | https://doi.org/10.1038/s41598-025-90943-y |
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