Drug delivery strategies to improve the treatment of corneal disorders
Anterior eye disorders including dry eye syndrome, keratitis, chemical burns, and trauma have varying prevalence rates in the world. Classical dosage forms based-topical ophthalmic drugs are popular treatments for managing corneal diseases. However, current dosage forms of ocular drugs can be associ...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025002610 |
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| author | Mahsa Fallah Tafti Zeinab Fayyaz Hossein Aghamollaei Khosrow Jadidi Shahab Faghihi |
| author_facet | Mahsa Fallah Tafti Zeinab Fayyaz Hossein Aghamollaei Khosrow Jadidi Shahab Faghihi |
| author_sort | Mahsa Fallah Tafti |
| collection | DOAJ |
| description | Anterior eye disorders including dry eye syndrome, keratitis, chemical burns, and trauma have varying prevalence rates in the world. Classical dosage forms based-topical ophthalmic drugs are popular treatments for managing corneal diseases. However, current dosage forms of ocular drugs can be associated with major challenges such as the short retention time in the presence of ocular barriers. Developing alternative therapeutic methods is required to overcome drug bioavailability from ocular barriers. Nanocarriers are major platforms and promising candidates for the administration of ophthalmic drugs in an adjustable manner. This paper briefly introduces the advantages, disadvantages, and characteristics of delivery systems for the treatment of corneal diseases. Additionally, advanced technologies such as 3D printing are being considered to fabricate ocular drug carriers and determine drug dosages for personalized treatment. This comprehensive review is gathered through multiple databases such as Google Scholar, PubMed, and Web of Science. It explores information around ''ocular drug delivery systems'', ''nano-based drug delivery systems'', ''engineered nanocarriers'', and ''advanced technologies to fabricate personalized drug delivery systems''. |
| format | Article |
| id | doaj-art-b1669e4e3a68439582738081ab6c1fa2 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-b1669e4e3a68439582738081ab6c1fa22025-02-02T05:28:27ZengElsevierHeliyon2405-84402025-01-01112e41881Drug delivery strategies to improve the treatment of corneal disordersMahsa Fallah Tafti0Zeinab Fayyaz1Hossein Aghamollaei2Khosrow Jadidi3Shahab Faghihi4Stem Cell and Regenerative Medicine Group, National Institute of Genetic Engineering and Biotechnology, Tehran 14965/161, IranEdison Biotechnology Institute, Ohio University, Athens, OH, 45701, USAChemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, IranVision Health Research Center, Semnan University of Medical Sciences, Semnan, IranStem Cell and Regenerative Medicine Group, National Institute of Genetic Engineering and Biotechnology, Tehran 14965/161, Iran; Corresponding author. Stem Cell and Regenerative Medicine Group, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran 14965/161, Iran.Anterior eye disorders including dry eye syndrome, keratitis, chemical burns, and trauma have varying prevalence rates in the world. Classical dosage forms based-topical ophthalmic drugs are popular treatments for managing corneal diseases. However, current dosage forms of ocular drugs can be associated with major challenges such as the short retention time in the presence of ocular barriers. Developing alternative therapeutic methods is required to overcome drug bioavailability from ocular barriers. Nanocarriers are major platforms and promising candidates for the administration of ophthalmic drugs in an adjustable manner. This paper briefly introduces the advantages, disadvantages, and characteristics of delivery systems for the treatment of corneal diseases. Additionally, advanced technologies such as 3D printing are being considered to fabricate ocular drug carriers and determine drug dosages for personalized treatment. This comprehensive review is gathered through multiple databases such as Google Scholar, PubMed, and Web of Science. It explores information around ''ocular drug delivery systems'', ''nano-based drug delivery systems'', ''engineered nanocarriers'', and ''advanced technologies to fabricate personalized drug delivery systems''.http://www.sciencedirect.com/science/article/pii/S2405844025002610Corneal disordersDrug delivery systemsPersonalized medicine3D printing |
| spellingShingle | Mahsa Fallah Tafti Zeinab Fayyaz Hossein Aghamollaei Khosrow Jadidi Shahab Faghihi Drug delivery strategies to improve the treatment of corneal disorders Heliyon Corneal disorders Drug delivery systems Personalized medicine 3D printing |
| title | Drug delivery strategies to improve the treatment of corneal disorders |
| title_full | Drug delivery strategies to improve the treatment of corneal disorders |
| title_fullStr | Drug delivery strategies to improve the treatment of corneal disorders |
| title_full_unstemmed | Drug delivery strategies to improve the treatment of corneal disorders |
| title_short | Drug delivery strategies to improve the treatment of corneal disorders |
| title_sort | drug delivery strategies to improve the treatment of corneal disorders |
| topic | Corneal disorders Drug delivery systems Personalized medicine 3D printing |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025002610 |
| work_keys_str_mv | AT mahsafallahtafti drugdeliverystrategiestoimprovethetreatmentofcornealdisorders AT zeinabfayyaz drugdeliverystrategiestoimprovethetreatmentofcornealdisorders AT hosseinaghamollaei drugdeliverystrategiestoimprovethetreatmentofcornealdisorders AT khosrowjadidi drugdeliverystrategiestoimprovethetreatmentofcornealdisorders AT shahabfaghihi drugdeliverystrategiestoimprovethetreatmentofcornealdisorders |