Unraveling the role of hypoxia-inducible factors in cutaneous melanoma: from mechanisms to therapeutic opportunities

Unraveling the role of hypoxia-inducible factors in cutaneous melanoma: from mechanisms to therapeutic opportunities

Abstract Hypoxia is a common feature of solid malignancies, including cutaneous melanoma (CM). Hypoxia-inducible factor (HIF)-1α and HIF-2α orchestrate cellular responses to hypoxia and coordinate a transcriptional program that promote several aggressive features in CM, such as angiogenesis, epithel...

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Bibliographic Details
Main Authors: Arianna Bellazzo, Barbara Montico, Roberto Guerrieri, Francesca Colizzi, Agostino Steffan, Jerry Polesel, Elisabetta Fratta
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cell Communication and Signaling
Subjects:
Cutaneous melanoma
Hypoxia-inducible factors
Hypoxia
Normoxia
Non-coding RNAs
Online Access:https://doi.org/10.1186/s12964-025-02173-4
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