Severe transient neonatal hyperinsulinism: First Peruvian case series
Congenital hyperinsulinism is characterized by dysregulated insulin secretion and is the most common and severe cause of persistent hypoglycemia in pediatrics. Brain damage rates can be as high as 50% due to inadequate treatment. Transient congenital hyperinsulinism is more frequent than permanent c...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-06-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X251347787 |
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| author | Manuel André Virú-Loza Francesca Bermudez-Paredes Isabel Milagros Arauco-Carhuas |
| author_facet | Manuel André Virú-Loza Francesca Bermudez-Paredes Isabel Milagros Arauco-Carhuas |
| author_sort | Manuel André Virú-Loza |
| collection | DOAJ |
| description | Congenital hyperinsulinism is characterized by dysregulated insulin secretion and is the most common and severe cause of persistent hypoglycemia in pediatrics. Brain damage rates can be as high as 50% due to inadequate treatment. Transient congenital hyperinsulinism is more frequent than permanent congenital hyperinsulinism. Acquired hyperinsulinism due to perinatal stress is often transient, too. Diazoxide is the first-line therapy. However, in Peru, reports about pediatric patients with hyperinsulinism treated with diazoxide are scarce. Our article describes the first Peruvian case series of severe transient neonatal hyperinsulinism treated with diazoxide, with good response and manageable adverse effects. Diazoxide should be included in the Single National Pharmaceutical Request Form for Essential Medicines of Peru to expedite the use of a medication as essential as this one. |
| format | Article |
| id | doaj-art-b16343cb7c474ca4b7ea0304a120e06c |
| institution | DOAJ |
| issn | 2050-313X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj-art-b16343cb7c474ca4b7ea0304a120e06c2025-08-20T03:20:55ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2025-06-011310.1177/2050313X251347787Severe transient neonatal hyperinsulinism: First Peruvian case seriesManuel André Virú-Loza0Francesca Bermudez-Paredes1Isabel Milagros Arauco-Carhuas2Unidad de Revisiones Sistemáticas y Meta-análisis, Vicerrectorado de Investigación, Universidad San Ignacio de Loyola, Lima, PeruADIECS Asociación para el Desarrollo de la Investigación Estudiantil en Ciencias de la Salud, Universidad Nacional Mayor de San Marcos, Lima, PeruADIECS Asociación para el Desarrollo de la Investigación Estudiantil en Ciencias de la Salud, Universidad Nacional Mayor de San Marcos, Lima, PeruCongenital hyperinsulinism is characterized by dysregulated insulin secretion and is the most common and severe cause of persistent hypoglycemia in pediatrics. Brain damage rates can be as high as 50% due to inadequate treatment. Transient congenital hyperinsulinism is more frequent than permanent congenital hyperinsulinism. Acquired hyperinsulinism due to perinatal stress is often transient, too. Diazoxide is the first-line therapy. However, in Peru, reports about pediatric patients with hyperinsulinism treated with diazoxide are scarce. Our article describes the first Peruvian case series of severe transient neonatal hyperinsulinism treated with diazoxide, with good response and manageable adverse effects. Diazoxide should be included in the Single National Pharmaceutical Request Form for Essential Medicines of Peru to expedite the use of a medication as essential as this one.https://doi.org/10.1177/2050313X251347787 |
| spellingShingle | Manuel André Virú-Loza Francesca Bermudez-Paredes Isabel Milagros Arauco-Carhuas Severe transient neonatal hyperinsulinism: First Peruvian case series SAGE Open Medical Case Reports |
| title | Severe transient neonatal hyperinsulinism: First Peruvian case series |
| title_full | Severe transient neonatal hyperinsulinism: First Peruvian case series |
| title_fullStr | Severe transient neonatal hyperinsulinism: First Peruvian case series |
| title_full_unstemmed | Severe transient neonatal hyperinsulinism: First Peruvian case series |
| title_short | Severe transient neonatal hyperinsulinism: First Peruvian case series |
| title_sort | severe transient neonatal hyperinsulinism first peruvian case series |
| url | https://doi.org/10.1177/2050313X251347787 |
| work_keys_str_mv | AT manuelandreviruloza severetransientneonatalhyperinsulinismfirstperuviancaseseries AT francescabermudezparedes severetransientneonatalhyperinsulinismfirstperuviancaseseries AT isabelmilagrosaraucocarhuas severetransientneonatalhyperinsulinismfirstperuviancaseseries |