Drug-drug interaction of paroxetine on olanzapine and initial dosage optimization in patients with major depressive disorder based on population pharmacokinetics

Drug-drug interaction of paroxetine on olanzapine and initial dosage optimization in patients with major depressive disorder based on population pharmacokinetics

ObjectiveOlanzapine is already used to treat patients with major depressive disorder; however, whether complex drug–drug interaction (DDI) has an effect on the pharmacokinetics of people using olanzapine and its initial dosage remains unknown. The present study aims to explore the effect of DDI on o...

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Bibliographic Details
Main Authors: Cun Zhang, Liang Chen, Yin-Yin Duan, Su-Mei He, Ya-Li Tian, Ying Gao, Dong-Dong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Psychiatry
Subjects:
drug-drug interaction
paroxetine
olanzapine
population pharmacokinetics
initial dosage
major depressive disorder
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1538996/full
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