Single-cell transcriptomics and machine learning unveil ferroptosis features in tumor-associated macrophages: Prognostic model and therapeutic strategies for lung adenocarcinoma

Single-cell transcriptomics and machine learning unveil ferroptosis features in tumor-associated macrophages: Prognostic model and therapeutic strategies for lung adenocarcinoma

BackgroundLung adenocarcinoma (LUAD) is a major cause of cancer-related mortality worldwide. Tumor-associated macrophages (TAMs) play a crucial role in the tumor microenvironment (TME), influencing tumor progression and immune response. Ferroptosis, an iron-dependent form of regulated cell death, ha...

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Bibliographic Details
Main Authors: Ting Ji, Juanli Jiang, Xin Wang, Kai Yang, Shaojin Wang, Bin Pan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
ferroptosis
lung adenocarcinoma (LUAD)
macrophage
prognosis
ferroptosis of macrophage
single-cell transcriptome analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1598756/full
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