Clinicopathologic Significance of HIF-1α, CXCR4, and VEGF Expression in Colon Cancer
We investigated the clinicopathologic significance of HIF-1, CXCR4, and VEGF expression using immumohistochemistry in human colon cancer. HIF-1, CXCR4, and VEGF high expression levels were correlated positively with TNM stage, lymph node involvement, and distant metastasis Furthermore, we found that...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2010/537531 |
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| author | Yugang Wu Min Jin Huanbai Xu Zhang Shimin Songbing He Liang Wang Yanyun Zhang |
| author_facet | Yugang Wu Min Jin Huanbai Xu Zhang Shimin Songbing He Liang Wang Yanyun Zhang |
| author_sort | Yugang Wu |
| collection | DOAJ |
| description | We investigated the clinicopathologic significance of HIF-1, CXCR4, and VEGF expression using immumohistochemistry in human colon cancer. HIF-1, CXCR4, and VEGF high expression levels were correlated positively with TNM stage, lymph node involvement, and distant metastasis Furthermore, we found that combined high expression of any two of the three molecules (P=.028 for HIF-1/CXCR4, P=.007 for HIF-1/VEGF, and P=.004 for CXCR4/VEGF) had stronger correlation with lymph node metastasis than did each alone. However, a relationship with distant metastasis is seen only with the combinations CXCR4/VEGF (P=.069 for HIF-1/CXCR4, P=.062 for HIF-1/VEGF, and P=.035 for CXCR4/VEGF) as compared with those of single molecule high expression alone. Combined expression of all three molecules strongly correlates with lymph node metastasis and distant metastasis. The mRNA expression of HIF-1, CXCR4, and VEGF were
quantified by real-time PCR in different colon cancer tissue samples, the experiment results shown that fresh colon tissue samples significantly overexpressed CXCR4 and VEGF mRNA compared with negative control. Therefore, the disease-free survival of all
patients after curative resection can be considered in association with all three markers expression. |
| format | Article |
| id | doaj-art-b1514eae4a224ed1bf921809e122dc5c |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-b1514eae4a224ed1bf921809e122dc5c2025-02-03T00:59:06ZengWileyClinical and Developmental Immunology1740-25221740-25302010-01-01201010.1155/2010/537531537531Clinicopathologic Significance of HIF-1α, CXCR4, and VEGF Expression in Colon CancerYugang Wu0Min Jin1Huanbai Xu2Zhang Shimin3Songbing He4Liang Wang5Yanyun Zhang6Department of Surgery, The First People Hospital of Changzhou and The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213000, ChinaKey Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences and Shanghai Jiao Tong University School of Medicine, Chinese Academy of Sciences, Shanghai 200025, ChinaKey Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences and Shanghai Jiao Tong University School of Medicine, Chinese Academy of Sciences, Shanghai 200025, ChinaKey Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences and Shanghai Jiao Tong University School of Medicine, Chinese Academy of Sciences, Shanghai 200025, ChinaDepartment of Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, ChinaDepartment of Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, ChinaKey Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences and Shanghai Jiao Tong University School of Medicine, Chinese Academy of Sciences, Shanghai 200025, ChinaWe investigated the clinicopathologic significance of HIF-1, CXCR4, and VEGF expression using immumohistochemistry in human colon cancer. HIF-1, CXCR4, and VEGF high expression levels were correlated positively with TNM stage, lymph node involvement, and distant metastasis Furthermore, we found that combined high expression of any two of the three molecules (P=.028 for HIF-1/CXCR4, P=.007 for HIF-1/VEGF, and P=.004 for CXCR4/VEGF) had stronger correlation with lymph node metastasis than did each alone. However, a relationship with distant metastasis is seen only with the combinations CXCR4/VEGF (P=.069 for HIF-1/CXCR4, P=.062 for HIF-1/VEGF, and P=.035 for CXCR4/VEGF) as compared with those of single molecule high expression alone. Combined expression of all three molecules strongly correlates with lymph node metastasis and distant metastasis. The mRNA expression of HIF-1, CXCR4, and VEGF were quantified by real-time PCR in different colon cancer tissue samples, the experiment results shown that fresh colon tissue samples significantly overexpressed CXCR4 and VEGF mRNA compared with negative control. Therefore, the disease-free survival of all patients after curative resection can be considered in association with all three markers expression.http://dx.doi.org/10.1155/2010/537531 |
| spellingShingle | Yugang Wu Min Jin Huanbai Xu Zhang Shimin Songbing He Liang Wang Yanyun Zhang Clinicopathologic Significance of HIF-1α, CXCR4, and VEGF Expression in Colon Cancer Clinical and Developmental Immunology |
| title | Clinicopathologic Significance of HIF-1α, CXCR4, and VEGF Expression in Colon Cancer |
| title_full | Clinicopathologic Significance of HIF-1α, CXCR4, and VEGF Expression in Colon Cancer |
| title_fullStr | Clinicopathologic Significance of HIF-1α, CXCR4, and VEGF Expression in Colon Cancer |
| title_full_unstemmed | Clinicopathologic Significance of HIF-1α, CXCR4, and VEGF Expression in Colon Cancer |
| title_short | Clinicopathologic Significance of HIF-1α, CXCR4, and VEGF Expression in Colon Cancer |
| title_sort | clinicopathologic significance of hif 1α cxcr4 and vegf expression in colon cancer |
| url | http://dx.doi.org/10.1155/2010/537531 |
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