Risk factors and a predictive model for mixed urinary incontinence among parous women: Insights from a large-scale multicenter epidemiological investigation
Purpose This study aims to identify independent risk factors for mixed urinary incontinence (MUI) in parous women using a multicenter epidemiological study and to establish and validate a predictive nomogram. Methods A large-scale survey was conducted from June 2022 to September 2023, including paro...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-04-01
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| Series: | Digital Health |
| Online Access: | https://doi.org/10.1177/20552076251333661 |
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| author | Qi Wang Stefano Manodoro Huifang Lin Xiaofang Li Chaoqin Lin Xiaoxiang Jiang |
| author_facet | Qi Wang Stefano Manodoro Huifang Lin Xiaofang Li Chaoqin Lin Xiaoxiang Jiang |
| author_sort | Qi Wang |
| collection | DOAJ |
| description | Purpose This study aims to identify independent risk factors for mixed urinary incontinence (MUI) in parous women using a multicenter epidemiological study and to establish and validate a predictive nomogram. Methods A large-scale survey was conducted from June 2022 to September 2023, including parous women aged over 20 selected through stratified random sampling. Data encompassed sociodemographic and obstetric histories, comorbidities, and standardized questionnaires. The primary goal was to identify high-risk factors for MUI, while the secondary was to develop a nomogram. Risk factors were determined using univariable and multivariable analyses. The nomogram's performance was assessed via concordance index (C-index) and calibration plots through internal and external validation. Results A total of 7709 women participated, with an MUI prevalence of 6.8%. Independent risk factors included higher body mass index, urban residence, postmenopausal status, multiple vaginal deliveries, history of pelvic surgery and macrosomia, family history of pelvic floor dysfunction, hypertension, and constipation. The area under the curve for the nomogram model was 0.717 in the training set, 0.714 for internal validation, and 0.725 for external validation. The calibration plots showed a good agreement between the predicted and observed outcomes. Conclusion This study identifies key risk factors for MUI in parous women and introduces a validated nomogram with high but not perfect predictive accuracy. The model enables early identification and management of MUI, though further refinement could enhance accuracy. |
| format | Article |
| id | doaj-art-b150115b72004228ab0f8d8b1cc7f3d9 |
| institution | DOAJ |
| issn | 2055-2076 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | SAGE Publishing |
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| series | Digital Health |
| spelling | doaj-art-b150115b72004228ab0f8d8b1cc7f3d92025-08-20T03:16:57ZengSAGE PublishingDigital Health2055-20762025-04-011110.1177/20552076251333661Risk factors and a predictive model for mixed urinary incontinence among parous women: Insights from a large-scale multicenter epidemiological investigationQi Wang0Stefano Manodoro1Huifang Lin2Xiaofang Li3Chaoqin Lin4Xiaoxiang Jiang5 Fujian Provincial Key Laboratory of Women and Children's Critical Diseases Research, Fuzhou, PR China , Milan, Italy Department of Gynecology and Obstetrics, Shaxian General Hospital, Sanming, PR China Pelvic Floor Rehabilitation Center, Beifeng Street Community Health Service Center, Quanzhou, PR China Fujian Provincial Key Laboratory of Women and Children's Critical Diseases Research, Fuzhou, PR China Fujian Provincial Key Laboratory of Women and Children's Critical Diseases Research, Fuzhou, PR ChinaPurpose This study aims to identify independent risk factors for mixed urinary incontinence (MUI) in parous women using a multicenter epidemiological study and to establish and validate a predictive nomogram. Methods A large-scale survey was conducted from June 2022 to September 2023, including parous women aged over 20 selected through stratified random sampling. Data encompassed sociodemographic and obstetric histories, comorbidities, and standardized questionnaires. The primary goal was to identify high-risk factors for MUI, while the secondary was to develop a nomogram. Risk factors were determined using univariable and multivariable analyses. The nomogram's performance was assessed via concordance index (C-index) and calibration plots through internal and external validation. Results A total of 7709 women participated, with an MUI prevalence of 6.8%. Independent risk factors included higher body mass index, urban residence, postmenopausal status, multiple vaginal deliveries, history of pelvic surgery and macrosomia, family history of pelvic floor dysfunction, hypertension, and constipation. The area under the curve for the nomogram model was 0.717 in the training set, 0.714 for internal validation, and 0.725 for external validation. The calibration plots showed a good agreement between the predicted and observed outcomes. Conclusion This study identifies key risk factors for MUI in parous women and introduces a validated nomogram with high but not perfect predictive accuracy. The model enables early identification and management of MUI, though further refinement could enhance accuracy.https://doi.org/10.1177/20552076251333661 |
| spellingShingle | Qi Wang Stefano Manodoro Huifang Lin Xiaofang Li Chaoqin Lin Xiaoxiang Jiang Risk factors and a predictive model for mixed urinary incontinence among parous women: Insights from a large-scale multicenter epidemiological investigation Digital Health |
| title | Risk factors and a predictive model for mixed urinary incontinence among parous women: Insights from a large-scale multicenter epidemiological investigation |
| title_full | Risk factors and a predictive model for mixed urinary incontinence among parous women: Insights from a large-scale multicenter epidemiological investigation |
| title_fullStr | Risk factors and a predictive model for mixed urinary incontinence among parous women: Insights from a large-scale multicenter epidemiological investigation |
| title_full_unstemmed | Risk factors and a predictive model for mixed urinary incontinence among parous women: Insights from a large-scale multicenter epidemiological investigation |
| title_short | Risk factors and a predictive model for mixed urinary incontinence among parous women: Insights from a large-scale multicenter epidemiological investigation |
| title_sort | risk factors and a predictive model for mixed urinary incontinence among parous women insights from a large scale multicenter epidemiological investigation |
| url | https://doi.org/10.1177/20552076251333661 |
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