Association of body mass index with morbidity in patients hospitalised with COVID-19
Purpose To evaluate the association between body mass index (BMI) and clinical outcomes other than death in patients hospitalised and intubated with COVID-19.Methods This is a single-centre cohort study of adults with COVID-19 admitted to New York Presbyterian Hospital-Weill Cornell Medicine from 3...
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| Language: | English |
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BMJ Publishing Group
2021-01-01
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| Series: | BMJ Open Respiratory Research |
| Online Access: | https://bmjopenrespres.bmj.com/content/8/1/e000970.full |
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| author | Hao Huang Monika M Safford Edward J Schenck Maria Plataki Di Pan Parag Goyal Katherine Hoffman Jacky Man Kwan Choi |
| author_facet | Hao Huang Monika M Safford Edward J Schenck Maria Plataki Di Pan Parag Goyal Katherine Hoffman Jacky Man Kwan Choi |
| author_sort | Hao Huang |
| collection | DOAJ |
| description | Purpose To evaluate the association between body mass index (BMI) and clinical outcomes other than death in patients hospitalised and intubated with COVID-19.Methods This is a single-centre cohort study of adults with COVID-19 admitted to New York Presbyterian Hospital-Weill Cornell Medicine from 3 March 2020 through 15 May 2020. Baseline and outcome variables, as well as lab and ventilatory parameters, were generated for the admitted and intubated cohorts after stratifying by BMI category. Linear regression models were used for continuous, and logistic regression models were used for categorical outcomes.Results The study included 1337 admitted patients with a subset of 407 intubated patients. Among admitted patients, hospital length of stay (LOS) and home discharge was not significantly different across BMI categories independent of demographic characteristics and comorbidities. In the intubated cohort, there was no difference in in-hospital events and treatments, including renal replacement therapy, neuromuscular blockade and prone positioning. Ventilatory ratio was higher with increasing BMI on days 1, 3 and 7. There was no significant difference in ventilator free days (VFD) at 28 or 60 days, need for tracheostomy, hospital LOS, and discharge disposition based on BMI in the intubated cohort after adjustment.Conclusions In our COVID-19 population, there was no association between obesity and morbidity outcomes, such as hospital LOS, home discharge or VFD. Further research is needed to clarify the mechanisms underlying the reported effects of BMI on outcomes, which may be population dependent. |
| format | Article |
| id | doaj-art-b14ac3fd27ee4a88ba55f12767feca51 |
| institution | OA Journals |
| issn | 2052-4439 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Respiratory Research |
| spelling | doaj-art-b14ac3fd27ee4a88ba55f12767feca512025-08-20T02:22:25ZengBMJ Publishing GroupBMJ Open Respiratory Research2052-44392021-01-018110.1136/bmjresp-2021-000970Association of body mass index with morbidity in patients hospitalised with COVID-19Hao Huang0Monika M Safford1Edward J Schenck2Maria Plataki3Di Pan4Parag Goyal5Katherine Hoffman6Jacky Man Kwan Choi7Cardiology, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, ChinaDivision of General Internal Medicine, Weill Cornell Medical College, New York, New York, USADivision of Pulmonary and Critical Care Medicine, Weill Cornell Medicine, New York, New York, USADepartment of Medicine, Division of Pulmonary Critical Care, New York Presbyterian Hospital - Weill Cornell Medicine, New York, New York, USADepartment of Medicine, Division of Pulmonary Critical Care, New York Presbyterian Hospital - Weill Cornell Medicine, New York, New York, USA10 Division of General Internal Medicine, Weill Cornell Medicine, New York, New York, USADepartment of Population Health Sciences, Division of Biostatistics, Weill Cornell Medicine, New York, New York, USADepartment of Population Health Sciences, Division of Biostatistics, Weill Cornell Medicine, New York, New York, USAPurpose To evaluate the association between body mass index (BMI) and clinical outcomes other than death in patients hospitalised and intubated with COVID-19.Methods This is a single-centre cohort study of adults with COVID-19 admitted to New York Presbyterian Hospital-Weill Cornell Medicine from 3 March 2020 through 15 May 2020. Baseline and outcome variables, as well as lab and ventilatory parameters, were generated for the admitted and intubated cohorts after stratifying by BMI category. Linear regression models were used for continuous, and logistic regression models were used for categorical outcomes.Results The study included 1337 admitted patients with a subset of 407 intubated patients. Among admitted patients, hospital length of stay (LOS) and home discharge was not significantly different across BMI categories independent of demographic characteristics and comorbidities. In the intubated cohort, there was no difference in in-hospital events and treatments, including renal replacement therapy, neuromuscular blockade and prone positioning. Ventilatory ratio was higher with increasing BMI on days 1, 3 and 7. There was no significant difference in ventilator free days (VFD) at 28 or 60 days, need for tracheostomy, hospital LOS, and discharge disposition based on BMI in the intubated cohort after adjustment.Conclusions In our COVID-19 population, there was no association between obesity and morbidity outcomes, such as hospital LOS, home discharge or VFD. Further research is needed to clarify the mechanisms underlying the reported effects of BMI on outcomes, which may be population dependent.https://bmjopenrespres.bmj.com/content/8/1/e000970.full |
| spellingShingle | Hao Huang Monika M Safford Edward J Schenck Maria Plataki Di Pan Parag Goyal Katherine Hoffman Jacky Man Kwan Choi Association of body mass index with morbidity in patients hospitalised with COVID-19 BMJ Open Respiratory Research |
| title | Association of body mass index with morbidity in patients hospitalised with COVID-19 |
| title_full | Association of body mass index with morbidity in patients hospitalised with COVID-19 |
| title_fullStr | Association of body mass index with morbidity in patients hospitalised with COVID-19 |
| title_full_unstemmed | Association of body mass index with morbidity in patients hospitalised with COVID-19 |
| title_short | Association of body mass index with morbidity in patients hospitalised with COVID-19 |
| title_sort | association of body mass index with morbidity in patients hospitalised with covid 19 |
| url | https://bmjopenrespres.bmj.com/content/8/1/e000970.full |
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