Post-treatment late and long-term effects in bone sarcoma: A scoping review
Despite the fact that chemotherapy for bone sarcomas (e.g. Ewing sarcoma, osteosarcoma) has well-reported toxicities and that surgical intervention is frequently life altering, follow-up care to monitor for late and long-term effects beyond that of oncological surveillance in former patients is vari...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Journal of Bone Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212137425000120 |
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| author | Kaainat Khan Kathleen Kane Zoe Davison Darrell Green |
| author_facet | Kaainat Khan Kathleen Kane Zoe Davison Darrell Green |
| author_sort | Kaainat Khan |
| collection | DOAJ |
| description | Despite the fact that chemotherapy for bone sarcomas (e.g. Ewing sarcoma, osteosarcoma) has well-reported toxicities and that surgical intervention is frequently life altering, follow-up care to monitor for late and long-term effects beyond that of oncological surveillance in former patients is variable. Anecdotal evidence suggests that inconsistent follow-up means some former bone sarcoma patients are left to cope with post-treatment late and long-term effects with limited support. Here, we performed a scoping review to provide a more empirical identification of the knowledge gaps and to provide an overview of the peer reviewed academic literature reporting the late and long-term effects of treatment for bone sarcoma. JBI Scoping Review Network guidelines for charting, analysis and data extraction were followed. Literature searches were conducted in Medline (Ovid), Cochrane CENTRAL, EMBASE (Ovid), CINAHL, PsycINFO, Proquest and Web of Science (Clarivate Analytics) from March 2024 to September 2024. Paper titles and abstracts were screened by two independent reviewers followed by full text analysis by the lead researcher. Seventy-four peer reviewed articles were included in the analysis. Most studies were of a retrospective study design, some up to 20 years of follow-up and included chemotherapy, surgery and sometimes radiotherapy as the treatment modality. Our analysis identified secondary malignancies, cardio- and nephrotoxicity, lower bone mineral density and microarchitectural deterioration, cancer related fatigue and motor neuropathies as the major physical late and long-term effects requiring dedicated follow-up. In some cases, follow-up may need to span decades, especially given the increasing population of former patients. Our results form the evidence-based foundations for future work that might include late and long-term effect follow-up service mapping exercises and expanded clinical recommendations. |
| format | Article |
| id | doaj-art-b146d50cfa48457f97a60873bb48b7dd |
| institution | OA Journals |
| issn | 2212-1374 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Bone Oncology |
| spelling | doaj-art-b146d50cfa48457f97a60873bb48b7dd2025-08-20T02:06:04ZengElsevierJournal of Bone Oncology2212-13742025-06-015210067110.1016/j.jbo.2025.100671Post-treatment late and long-term effects in bone sarcoma: A scoping reviewKaainat Khan0Kathleen Kane1Zoe Davison2Darrell Green3Biomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United KingdomBone Cancer Research Trust, Leeds, United KingdomBone Cancer Research Trust, Leeds, United KingdomBiomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom; Corresponding author.Despite the fact that chemotherapy for bone sarcomas (e.g. Ewing sarcoma, osteosarcoma) has well-reported toxicities and that surgical intervention is frequently life altering, follow-up care to monitor for late and long-term effects beyond that of oncological surveillance in former patients is variable. Anecdotal evidence suggests that inconsistent follow-up means some former bone sarcoma patients are left to cope with post-treatment late and long-term effects with limited support. Here, we performed a scoping review to provide a more empirical identification of the knowledge gaps and to provide an overview of the peer reviewed academic literature reporting the late and long-term effects of treatment for bone sarcoma. JBI Scoping Review Network guidelines for charting, analysis and data extraction were followed. Literature searches were conducted in Medline (Ovid), Cochrane CENTRAL, EMBASE (Ovid), CINAHL, PsycINFO, Proquest and Web of Science (Clarivate Analytics) from March 2024 to September 2024. Paper titles and abstracts were screened by two independent reviewers followed by full text analysis by the lead researcher. Seventy-four peer reviewed articles were included in the analysis. Most studies were of a retrospective study design, some up to 20 years of follow-up and included chemotherapy, surgery and sometimes radiotherapy as the treatment modality. Our analysis identified secondary malignancies, cardio- and nephrotoxicity, lower bone mineral density and microarchitectural deterioration, cancer related fatigue and motor neuropathies as the major physical late and long-term effects requiring dedicated follow-up. In some cases, follow-up may need to span decades, especially given the increasing population of former patients. Our results form the evidence-based foundations for future work that might include late and long-term effect follow-up service mapping exercises and expanded clinical recommendations.http://www.sciencedirect.com/science/article/pii/S2212137425000120Bone sarcomaCancerLate effectsChemotherapySurvivorship |
| spellingShingle | Kaainat Khan Kathleen Kane Zoe Davison Darrell Green Post-treatment late and long-term effects in bone sarcoma: A scoping review Journal of Bone Oncology Bone sarcoma Cancer Late effects Chemotherapy Survivorship |
| title | Post-treatment late and long-term effects in bone sarcoma: A scoping review |
| title_full | Post-treatment late and long-term effects in bone sarcoma: A scoping review |
| title_fullStr | Post-treatment late and long-term effects in bone sarcoma: A scoping review |
| title_full_unstemmed | Post-treatment late and long-term effects in bone sarcoma: A scoping review |
| title_short | Post-treatment late and long-term effects in bone sarcoma: A scoping review |
| title_sort | post treatment late and long term effects in bone sarcoma a scoping review |
| topic | Bone sarcoma Cancer Late effects Chemotherapy Survivorship |
| url | http://www.sciencedirect.com/science/article/pii/S2212137425000120 |
| work_keys_str_mv | AT kaainatkhan posttreatmentlateandlongtermeffectsinbonesarcomaascopingreview AT kathleenkane posttreatmentlateandlongtermeffectsinbonesarcomaascopingreview AT zoedavison posttreatmentlateandlongtermeffectsinbonesarcomaascopingreview AT darrellgreen posttreatmentlateandlongtermeffectsinbonesarcomaascopingreview |