m276-SL-PBD eradicates tumors and instigates long-lasting tumor-free survival in Merkel cell carcinoma preclinical models

m276-SL-PBD eradicates tumors and instigates long-lasting tumor-free survival in Merkel cell carcinoma preclinical models

Summary: Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine carcinoma, and immune checkpoint inhibitors (ICIs) are the only approved therapy; nonetheless, resistance is notable and there is a critical need for novel effective therapies. Recently, CD276 was identified as a promising...

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Bibliographic Details
Main Authors: Mikaela D. Kunika, Aarthi Kannan, Graham J. Velasco, Yang Feng, Steven Seaman, Bhaba K. Das, Dillon Pham, Nils Lambrecht, Haibo Zhao, Brad St. Croix, Ling Gao
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:iScience
Subjects:
therapeutic procedure
biotechnology
cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225006972
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