Cyotkines as Potential Therapies for Human Immunodeficiency Virus Infections
Cytokines are attracting increased interest as potential therapies for human immunodeficiency virus (HIV) infections. This attraction has particularly arisen as these cytokines have become more commercially available through recombinant technologies. This review focuses on the effects of these biolo...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1994-01-01
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| Series: | Canadian Journal of Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/1994/967945 |
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| Summary: | Cytokines are attracting increased interest
as potential therapies for human immunodeficiency virus (HIV) infections. This attraction has particularly
arisen as these cytokines have become more commercially available through recombinant technologies.
This review focuses on the effects of these biological response modifiers on preclinical HIV and related
retrovirus infections. Cytokines that have particularly been considered for HIV disease control include:
interferons -α , -β and -γ, interleukins-2. -3. -4. -6 and -7; tumour necrosis factors -α and -β; and the colony
stimulating factors. Efficacy has especially been seen when these cytokines have been used in combination
with the more conventional antiviral agents. Due to the many biological functions exerted by cytokines and
their interweaving of biological effects with other cytokines, they appear to have the potential to both inhibit
as well as enhance viral infections, depending upon how they are used, and caution is therefore urged in
their use. |
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| ISSN: | 1180-2332 |