Circadian Variation in the Onset of Placental Abruption
Objective. To determine circadian variation in the onset of placental abruption. Methods. A retrospective study involving 115 placental abruptions, divided into four subgroups based on initial symptoms comprising abdominal pain, vaginal bleeding, both abdominal pain and bleeding, or other symptoms....
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2017/3194814 |
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| _version_ | 1832556769690255360 |
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| author | Masanao Ohhashi Seishi Furukawa Hiroshi Sameshima |
| author_facet | Masanao Ohhashi Seishi Furukawa Hiroshi Sameshima |
| author_sort | Masanao Ohhashi |
| collection | DOAJ |
| description | Objective. To determine circadian variation in the onset of placental abruption. Methods. A retrospective study involving 115 placental abruptions, divided into four subgroups based on initial symptoms comprising abdominal pain, vaginal bleeding, both abdominal pain and bleeding, or other symptoms. The time of the initial symptom was considered the disease onset. We analyzed the frequency of disease onset and adverse perinatal outcome including perinatal death relative to the daily four 6-hour intervals. Results. Abdominal pain displayed significant circadian variation regarding the period of onset with higher levels from 0:00 AM to 6:00 AM (65%) compared with 0:00 PM to 6:00 PM (24%, p<0.01). Vaginal bleeding did not display significant circadian variation (p=0.45). Adverse perinatal outcome showed significant circadian variation with a higher occurrence of perinatal death from 0:00 AM to 6:00 AM (35%) compared with 0:00 PM to 6:00 PM (0%, p<0.01). After adjustment using variables of abdominal pain and time period, both variables significantly affected perinatal death (odds ratio: 13.0 and 2.2, resp.). The risk of adverse perinatal outcome increased significantly when abdominal pain occurred, except for the period 0:00 PM to 6:00 PM (OR, 9.5). Conclusion. Placental abruption beginning with abdominal pain has circadian variation. |
| format | Article |
| id | doaj-art-b13c62079f7547f486b901730b668ca4 |
| institution | Kabale University |
| issn | 2090-2727 2090-2735 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-b13c62079f7547f486b901730b668ca42025-02-03T05:44:28ZengWileyJournal of Pregnancy2090-27272090-27352017-01-01201710.1155/2017/31948143194814Circadian Variation in the Onset of Placental AbruptionMasanao Ohhashi0Seishi Furukawa1Hiroshi Sameshima2Department of Obstetrics & Gynecology, Faculty of Medicine, University of Miyazaki, Miyazaki, JapanDepartment of Obstetrics & Gynecology, School of Medicine, Kyorin University, Tokyo, JapanDepartment of Obstetrics & Gynecology, Faculty of Medicine, University of Miyazaki, Miyazaki, JapanObjective. To determine circadian variation in the onset of placental abruption. Methods. A retrospective study involving 115 placental abruptions, divided into four subgroups based on initial symptoms comprising abdominal pain, vaginal bleeding, both abdominal pain and bleeding, or other symptoms. The time of the initial symptom was considered the disease onset. We analyzed the frequency of disease onset and adverse perinatal outcome including perinatal death relative to the daily four 6-hour intervals. Results. Abdominal pain displayed significant circadian variation regarding the period of onset with higher levels from 0:00 AM to 6:00 AM (65%) compared with 0:00 PM to 6:00 PM (24%, p<0.01). Vaginal bleeding did not display significant circadian variation (p=0.45). Adverse perinatal outcome showed significant circadian variation with a higher occurrence of perinatal death from 0:00 AM to 6:00 AM (35%) compared with 0:00 PM to 6:00 PM (0%, p<0.01). After adjustment using variables of abdominal pain and time period, both variables significantly affected perinatal death (odds ratio: 13.0 and 2.2, resp.). The risk of adverse perinatal outcome increased significantly when abdominal pain occurred, except for the period 0:00 PM to 6:00 PM (OR, 9.5). Conclusion. Placental abruption beginning with abdominal pain has circadian variation.http://dx.doi.org/10.1155/2017/3194814 |
| spellingShingle | Masanao Ohhashi Seishi Furukawa Hiroshi Sameshima Circadian Variation in the Onset of Placental Abruption Journal of Pregnancy |
| title | Circadian Variation in the Onset of Placental Abruption |
| title_full | Circadian Variation in the Onset of Placental Abruption |
| title_fullStr | Circadian Variation in the Onset of Placental Abruption |
| title_full_unstemmed | Circadian Variation in the Onset of Placental Abruption |
| title_short | Circadian Variation in the Onset of Placental Abruption |
| title_sort | circadian variation in the onset of placental abruption |
| url | http://dx.doi.org/10.1155/2017/3194814 |
| work_keys_str_mv | AT masanaoohhashi circadianvariationintheonsetofplacentalabruption AT seishifurukawa circadianvariationintheonsetofplacentalabruption AT hiroshisameshima circadianvariationintheonsetofplacentalabruption |