Sirt6 overexpression relieves ferroptosis and delays the progression of diabetic nephropathy via Nrf2/GPX4 pathway

Sirt6 overexpression relieves ferroptosis and delays the progression of diabetic nephropathy via Nrf2/GPX4 pathway

Objective Sirt6, reactive oxygen species and ferroptosis may participate in the pathogenesis of Diabetic Nephropathy (DN). Exploring the relationship between Sirt6, oxidative stress, and ferroptosis provides new scientific ideas to DN.Methods Human podocytes were stimulated with 30 mM glucose and 5....

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Bibliographic Details
Main Authors: Lingyu Du, Canghui Guo, Shengnan Zeng, Ke Yu, Maodong Liu, Ying Li
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Renal Failure
Subjects:
Diabetic nephropathy
Sirt6
podocytes
mitochondrial dysfunction
ferroptosis
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2024.2377785
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