MAM kinases: physiological roles, related diseases, and therapeutic perspectives—a systematic review
Abstract Mitochondria-associated membranes (MAMs) are tethering regions amid the membranes of the endoplasmic reticulum (ER) and mitochondria. They are a lipid raft-like structure occupied by various proteins that facilitates signal transduction between the two organelles. The MAM proteome participa...
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BMC
2025-03-01
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| Series: | Cellular & Molecular Biology Letters |
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| Online Access: | https://doi.org/10.1186/s11658-025-00714-w |
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| author | A. Anjana Mohan Priti Talwar |
| author_facet | A. Anjana Mohan Priti Talwar |
| author_sort | A. Anjana Mohan |
| collection | DOAJ |
| description | Abstract Mitochondria-associated membranes (MAMs) are tethering regions amid the membranes of the endoplasmic reticulum (ER) and mitochondria. They are a lipid raft-like structure occupied by various proteins that facilitates signal transduction between the two organelles. The MAM proteome participates in cellular functions such as calcium (Ca2+) homeostasis, lipid synthesis, ER stress, inflammation, autophagy, mitophagy, and apoptosis. The human kinome is a superfamily of homologous proteins consisting of 538 kinases. MAM-associated kinases participate in the aforementioned cellular functions and act as cell fate executors. Studies have proved the dysregulated kinase interactions in MAM as an etiology for various diseases including cancer, diabetes mellitus, neurodegenerative diseases, cardiovascular diseases (CVDs), and obesity. Several small kinase inhibitory molecules have been well explored as promising drug candidates in clinical trials with an accelerating impact in the field of precision medicine. This review narrates the physiological actions, pathophysiology, and therapeutic potential of MAM-associated kinases with recent updates in the field. Graphical Abstract |
| format | Article |
| id | doaj-art-b13bbf57af884df88ef5af45b9db264c |
| institution | Kabale University |
| issn | 1689-1392 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Cellular & Molecular Biology Letters |
| spelling | doaj-art-b13bbf57af884df88ef5af45b9db264c2025-08-20T03:40:44ZengBMCCellular & Molecular Biology Letters1689-13922025-03-0130114010.1186/s11658-025-00714-wMAM kinases: physiological roles, related diseases, and therapeutic perspectives—a systematic reviewA. Anjana Mohan0Priti Talwar1Apoptosis and Cell Survival Research Laboratory, 412G Pearl Research Park, Department of Biosciences, School of Biosciences and Technology, Vellore Institute of TechnologyApoptosis and Cell Survival Research Laboratory, 412G Pearl Research Park, Department of Biosciences, School of Biosciences and Technology, Vellore Institute of TechnologyAbstract Mitochondria-associated membranes (MAMs) are tethering regions amid the membranes of the endoplasmic reticulum (ER) and mitochondria. They are a lipid raft-like structure occupied by various proteins that facilitates signal transduction between the two organelles. The MAM proteome participates in cellular functions such as calcium (Ca2+) homeostasis, lipid synthesis, ER stress, inflammation, autophagy, mitophagy, and apoptosis. The human kinome is a superfamily of homologous proteins consisting of 538 kinases. MAM-associated kinases participate in the aforementioned cellular functions and act as cell fate executors. Studies have proved the dysregulated kinase interactions in MAM as an etiology for various diseases including cancer, diabetes mellitus, neurodegenerative diseases, cardiovascular diseases (CVDs), and obesity. Several small kinase inhibitory molecules have been well explored as promising drug candidates in clinical trials with an accelerating impact in the field of precision medicine. This review narrates the physiological actions, pathophysiology, and therapeutic potential of MAM-associated kinases with recent updates in the field. Graphical Abstracthttps://doi.org/10.1186/s11658-025-00714-wMAMKinasesER stressMitophagyNeurodegenerative diseaseCancer |
| spellingShingle | A. Anjana Mohan Priti Talwar MAM kinases: physiological roles, related diseases, and therapeutic perspectives—a systematic review Cellular & Molecular Biology Letters MAM Kinases ER stress Mitophagy Neurodegenerative disease Cancer |
| title | MAM kinases: physiological roles, related diseases, and therapeutic perspectives—a systematic review |
| title_full | MAM kinases: physiological roles, related diseases, and therapeutic perspectives—a systematic review |
| title_fullStr | MAM kinases: physiological roles, related diseases, and therapeutic perspectives—a systematic review |
| title_full_unstemmed | MAM kinases: physiological roles, related diseases, and therapeutic perspectives—a systematic review |
| title_short | MAM kinases: physiological roles, related diseases, and therapeutic perspectives—a systematic review |
| title_sort | mam kinases physiological roles related diseases and therapeutic perspectives a systematic review |
| topic | MAM Kinases ER stress Mitophagy Neurodegenerative disease Cancer |
| url | https://doi.org/10.1186/s11658-025-00714-w |
| work_keys_str_mv | AT aanjanamohan mamkinasesphysiologicalrolesrelateddiseasesandtherapeuticperspectivesasystematicreview AT prititalwar mamkinasesphysiologicalrolesrelateddiseasesandtherapeuticperspectivesasystematicreview |