The Role of Environmental Endocrine Disruptors on Leydig Cell Death and Senescence
Environmental endocrine disruptors, as exogenous chemicals that interfere with hormonal behavior, are known to cause testicular Leydig cell death and senescence. The incidence of diseases of the male reproductive system has been increasing over the past half-century. Genetic defects alone cannot e...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society for Sexual Medicine and Andrology
2025-07-01
|
| Series: | The World Journal of Men's Health |
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850166050846408704 |
|---|---|
| author | Fang Yang Xiaoya Li Meijing Wang Xiucheng Lan Jingyi Zhang Junjun Li Degui Chang Xujun Yu |
| author_facet | Fang Yang Xiaoya Li Meijing Wang Xiucheng Lan Jingyi Zhang Junjun Li Degui Chang Xujun Yu |
| author_sort | Fang Yang |
| collection | DOAJ |
| description | Environmental endocrine disruptors, as exogenous chemicals that interfere with hormonal behavior, are known to cause testicular
Leydig cell death and senescence. The incidence of diseases of the male reproductive system has been increasing over the
past half-century. Genetic defects alone cannot explain the rapid increase in incidence, and there is growing evidence that environmental
factors or lifestyle changes are responsible for the high incidence in recent years. Testicular Leydig cells occupy an
important role in the male reproductive system. In this study, we review the mechanisms by which environmental endocrine
disruptors promote both death and senescence of testicular Leydig cells, refine the former into two programmed death modes,
apoptosis, and autophagy, and further explore the interactions among them, thus summarizing the advances of the toxic effects
of environmental endocrine disruptors on testicular Leydig cells, and expecting to provide a new therapeutic idea. |
| format | Article |
| id | doaj-art-b13a7ca391db469dbb76d74ce3ad47d3 |
| institution | OA Journals |
| issn | 2287-4208 2287-4690 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Korean Society for Sexual Medicine and Andrology |
| record_format | Article |
| series | The World Journal of Men's Health |
| spelling | doaj-art-b13a7ca391db469dbb76d74ce3ad47d32025-08-20T02:21:34ZengKorean Society for Sexual Medicine and AndrologyThe World Journal of Men's Health2287-42082287-46902025-07-0143347749110.5534/wjmh.240254The Role of Environmental Endocrine Disruptors on Leydig Cell Death and SenescenceFang Yang0https://orcid.org/0000-0002-3964-1791Xiaoya Li1https://orcid.org/0009-0005-3543-6589Meijing Wang2https://orcid.org/0000-0002-8292-8616Xiucheng Lan3https://orcid.org/0000-0001-9830-3525Jingyi Zhang4https://orcid.org/0000-0002-7977-0336Junjun Li5https://orcid.org/0000-0002-2956-9079Degui Chang6https://orcid.org/0009-0006-8752-8677Xujun Yu7https://orcid.org/0000-0002-5620-6783TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaChengdu Fifth People’s Hospital, Chengdu, ChinaTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaEnvironmental endocrine disruptors, as exogenous chemicals that interfere with hormonal behavior, are known to cause testicular Leydig cell death and senescence. The incidence of diseases of the male reproductive system has been increasing over the past half-century. Genetic defects alone cannot explain the rapid increase in incidence, and there is growing evidence that environmental factors or lifestyle changes are responsible for the high incidence in recent years. Testicular Leydig cells occupy an important role in the male reproductive system. In this study, we review the mechanisms by which environmental endocrine disruptors promote both death and senescence of testicular Leydig cells, refine the former into two programmed death modes, apoptosis, and autophagy, and further explore the interactions among them, thus summarizing the advances of the toxic effects of environmental endocrine disruptors on testicular Leydig cells, and expecting to provide a new therapeutic idea.apoptosisautophagycellular senescenceendocrine disruptorsleydig cells |
| spellingShingle | Fang Yang Xiaoya Li Meijing Wang Xiucheng Lan Jingyi Zhang Junjun Li Degui Chang Xujun Yu The Role of Environmental Endocrine Disruptors on Leydig Cell Death and Senescence The World Journal of Men's Health apoptosis autophagy cellular senescence endocrine disruptors leydig cells |
| title | The Role of Environmental Endocrine Disruptors on Leydig Cell Death and Senescence |
| title_full | The Role of Environmental Endocrine Disruptors on Leydig Cell Death and Senescence |
| title_fullStr | The Role of Environmental Endocrine Disruptors on Leydig Cell Death and Senescence |
| title_full_unstemmed | The Role of Environmental Endocrine Disruptors on Leydig Cell Death and Senescence |
| title_short | The Role of Environmental Endocrine Disruptors on Leydig Cell Death and Senescence |
| title_sort | role of environmental endocrine disruptors on leydig cell death and senescence |
| topic | apoptosis autophagy cellular senescence endocrine disruptors leydig cells |
| work_keys_str_mv | AT fangyang theroleofenvironmentalendocrinedisruptorsonleydigcelldeathandsenescence AT xiaoyali theroleofenvironmentalendocrinedisruptorsonleydigcelldeathandsenescence AT meijingwang theroleofenvironmentalendocrinedisruptorsonleydigcelldeathandsenescence AT xiuchenglan theroleofenvironmentalendocrinedisruptorsonleydigcelldeathandsenescence AT jingyizhang theroleofenvironmentalendocrinedisruptorsonleydigcelldeathandsenescence AT junjunli theroleofenvironmentalendocrinedisruptorsonleydigcelldeathandsenescence AT deguichang theroleofenvironmentalendocrinedisruptorsonleydigcelldeathandsenescence AT xujunyu theroleofenvironmentalendocrinedisruptorsonleydigcelldeathandsenescence AT fangyang roleofenvironmentalendocrinedisruptorsonleydigcelldeathandsenescence AT xiaoyali roleofenvironmentalendocrinedisruptorsonleydigcelldeathandsenescence AT meijingwang roleofenvironmentalendocrinedisruptorsonleydigcelldeathandsenescence AT xiuchenglan roleofenvironmentalendocrinedisruptorsonleydigcelldeathandsenescence AT jingyizhang roleofenvironmentalendocrinedisruptorsonleydigcelldeathandsenescence AT junjunli roleofenvironmentalendocrinedisruptorsonleydigcelldeathandsenescence AT deguichang roleofenvironmentalendocrinedisruptorsonleydigcelldeathandsenescence AT xujunyu roleofenvironmentalendocrinedisruptorsonleydigcelldeathandsenescence |