The Role of Environmental Endocrine Disruptors on Leydig Cell Death and Senescence
Environmental endocrine disruptors, as exogenous chemicals that interfere with hormonal behavior, are known to cause testicular Leydig cell death and senescence. The incidence of diseases of the male reproductive system has been increasing over the past half-century. Genetic defects alone cannot e...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Society for Sexual Medicine and Andrology
2025-07-01
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| Series: | The World Journal of Men's Health |
| Subjects: | |
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| Summary: | Environmental endocrine disruptors, as exogenous chemicals that interfere with hormonal behavior, are known to cause testicular
Leydig cell death and senescence. The incidence of diseases of the male reproductive system has been increasing over the
past half-century. Genetic defects alone cannot explain the rapid increase in incidence, and there is growing evidence that environmental
factors or lifestyle changes are responsible for the high incidence in recent years. Testicular Leydig cells occupy an
important role in the male reproductive system. In this study, we review the mechanisms by which environmental endocrine
disruptors promote both death and senescence of testicular Leydig cells, refine the former into two programmed death modes,
apoptosis, and autophagy, and further explore the interactions among them, thus summarizing the advances of the toxic effects
of environmental endocrine disruptors on testicular Leydig cells, and expecting to provide a new therapeutic idea. |
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| ISSN: | 2287-4208 2287-4690 |