Association of polysocial risk score, cardiovascular health status, and the risk of premature mortality: Findings from the UK Biobank
Background: Evidence of the cumulative effects of social risk factors on premature mortality is quite limited. We aimed to examine the association between cumulative social risk factors and premature mortality by constructing a polysocial risk score, and to explore the influence of cardiovascular he...
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Elsevier
2025-05-01
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| Series: | The Journal of Nutrition, Health and Aging |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1279770725000508 |
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| author | Wenqi Shen Lingli Cai Bin Wang Jiang Li Ying Sun Ningjian Wang Yingli Lu |
| author_facet | Wenqi Shen Lingli Cai Bin Wang Jiang Li Ying Sun Ningjian Wang Yingli Lu |
| author_sort | Wenqi Shen |
| collection | DOAJ |
| description | Background: Evidence of the cumulative effects of social risk factors on premature mortality is quite limited. We aimed to examine the association between cumulative social risk factors and premature mortality by constructing a polysocial risk score, and to explore the influence of cardiovascular health on this association. Methods: A polysocial risk score was constructed by summing 11 social determinants of health. A cardiovascular health (CVH) score was calculated following the algorithm of ''Life’s Essential 8”. Premature mortality was defined as death at an age younger than 75. Cox proportional hazards model was conducted. Results: A total of 314,039 participants in the UK Biobank were included (median age 56.0 years, 53.1% women). During a median of 12.7 years of follow-up, 13,888 premature deaths were reported. Compared with participants who had a low polysocial risk score (≤3), participants with a high polysocial risk score (≥7) were more than twice as likely to die prematurely in the follow-up period (HR 2.18, 95% CI 2.06–2.30). Compared with participants with ideal CVH and low polysocial risk score, those with poor CVH and high polysocial risk score had the highest risk of premature mortality (HR 5.25, 95% CI 4.48–6.14). A significant interaction was found between CVH status and polysocial risk score on premature mortality risk (P for interaction <0.001). Conclusions: Polysocial risk score was associated with an increased risk of premature mortality, the association was exacerbated by poor CVH. Our findings indicate that limiting social inequities and encouraging people to achieve an ideal CVH are essential to reducing the burden of premature mortality. |
| format | Article |
| id | doaj-art-b13545c43e354536bd92fcbefcbe4108 |
| institution | OA Journals |
| issn | 1760-4788 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Journal of Nutrition, Health and Aging |
| spelling | doaj-art-b13545c43e354536bd92fcbefcbe41082025-08-20T02:13:53ZengElsevierThe Journal of Nutrition, Health and Aging1760-47882025-05-0129510052710.1016/j.jnha.2025.100527Association of polysocial risk score, cardiovascular health status, and the risk of premature mortality: Findings from the UK BiobankWenqi Shen0Lingli Cai1Bin Wang2Jiang Li3Ying Sun4Ningjian Wang5Yingli Lu6Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaInstitute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCorresponding authors.; Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCorresponding authors.; Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaBackground: Evidence of the cumulative effects of social risk factors on premature mortality is quite limited. We aimed to examine the association between cumulative social risk factors and premature mortality by constructing a polysocial risk score, and to explore the influence of cardiovascular health on this association. Methods: A polysocial risk score was constructed by summing 11 social determinants of health. A cardiovascular health (CVH) score was calculated following the algorithm of ''Life’s Essential 8”. Premature mortality was defined as death at an age younger than 75. Cox proportional hazards model was conducted. Results: A total of 314,039 participants in the UK Biobank were included (median age 56.0 years, 53.1% women). During a median of 12.7 years of follow-up, 13,888 premature deaths were reported. Compared with participants who had a low polysocial risk score (≤3), participants with a high polysocial risk score (≥7) were more than twice as likely to die prematurely in the follow-up period (HR 2.18, 95% CI 2.06–2.30). Compared with participants with ideal CVH and low polysocial risk score, those with poor CVH and high polysocial risk score had the highest risk of premature mortality (HR 5.25, 95% CI 4.48–6.14). A significant interaction was found between CVH status and polysocial risk score on premature mortality risk (P for interaction <0.001). Conclusions: Polysocial risk score was associated with an increased risk of premature mortality, the association was exacerbated by poor CVH. Our findings indicate that limiting social inequities and encouraging people to achieve an ideal CVH are essential to reducing the burden of premature mortality.http://www.sciencedirect.com/science/article/pii/S1279770725000508Polysocial risk scorePremature mortalityCardiovascular healthSocial determinants of health |
| spellingShingle | Wenqi Shen Lingli Cai Bin Wang Jiang Li Ying Sun Ningjian Wang Yingli Lu Association of polysocial risk score, cardiovascular health status, and the risk of premature mortality: Findings from the UK Biobank The Journal of Nutrition, Health and Aging Polysocial risk score Premature mortality Cardiovascular health Social determinants of health |
| title | Association of polysocial risk score, cardiovascular health status, and the risk of premature mortality: Findings from the UK Biobank |
| title_full | Association of polysocial risk score, cardiovascular health status, and the risk of premature mortality: Findings from the UK Biobank |
| title_fullStr | Association of polysocial risk score, cardiovascular health status, and the risk of premature mortality: Findings from the UK Biobank |
| title_full_unstemmed | Association of polysocial risk score, cardiovascular health status, and the risk of premature mortality: Findings from the UK Biobank |
| title_short | Association of polysocial risk score, cardiovascular health status, and the risk of premature mortality: Findings from the UK Biobank |
| title_sort | association of polysocial risk score cardiovascular health status and the risk of premature mortality findings from the uk biobank |
| topic | Polysocial risk score Premature mortality Cardiovascular health Social determinants of health |
| url | http://www.sciencedirect.com/science/article/pii/S1279770725000508 |
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