A mathematical modelling framework for the regulation of intra-cellular OCT4 in human pluripotent stem cells.

A mathematical modelling framework for the regulation of intra-cellular OCT4 in human pluripotent stem cells.

Human pluripotent stem cells (hPSCs) have the potential to differentiate into all cell types, a property known as pluripotency. A deeper understanding of how pluripotency is regulated is required to assist in controlling pluripotency and differentiation trajectories experimentally. Mathematical mode...

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Bibliographic Details
Main Authors: L E Wadkin, S Orozco-Fuentes, I Neganova, M Lako, N G Parker, A Shukurov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0254991&type=printable
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