Expression of costimulatory molecule CD70 is prognostic in small cell lung cancer

Expression of costimulatory molecule CD70 is prognostic in small cell lung cancer

Abstract Introduction Small cell lung cancer (SCLC) is a highly aggressive malignancy with poor survival outcomes. The CD70-CD27 axis has been implicated in immune regulation and tumor progression across cancers, but its role in SCLC has not yet been elucidated. This research explores the expression...

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Main Authors: David Dora, Zsolt Megyesfalvi, Imre Vörös, Ágnes Paál, Peter Takacs, Daniela Dobos, Bence Lőrincz, Syeda Mahak Zahra Bokhari, Kenan Aloss, Gergely Pallag, Christopher Rivard, Hui Yu, Fred R. Hirsch, Anikó Görbe, Zoltán V. Varga, Zoltan Lohinai, Balazs Dome
Format: Article
Language:English
Published: Springer 2025-04-01
Series:Cancer Immunology, Immunotherapy
Subjects:
Small-cell lung cancer
CD70
CD27
B-cell
TLS
Tumor microenvironment
Online Access:https://doi.org/10.1007/s00262-025-04006-2
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