Synthesis of Magnolignan, a New Pigment Lightening Component, via a Suzuki-Miyaura Reaction
Magnolignan, 2,2′-dihydroxy-5,5′-dipropyl-biphenyl (1), is a down-regulator of melanin synthesis that inhibits the maturation of tyrosinase. In this study, a concise total synthesis of 1 was achieved in five steps with 50% overall yield starting from commercially available trans-anethole (2) via a S...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/686242 |
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| author | Shuhei Narita Tetsuhiro Ogura Toyonobu Usuki |
| author_facet | Shuhei Narita Tetsuhiro Ogura Toyonobu Usuki |
| author_sort | Shuhei Narita |
| collection | DOAJ |
| description | Magnolignan, 2,2′-dihydroxy-5,5′-dipropyl-biphenyl (1), is a down-regulator of melanin synthesis that inhibits the maturation of tyrosinase. In this study, a concise total synthesis of 1 was achieved in five steps with 50% overall yield starting from commercially available trans-anethole (2) via a Suzuki-Miyaura reaction. |
| format | Article |
| id | doaj-art-b12e510d8ac847e8a22099867586ae61 |
| institution | OA Journals |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-b12e510d8ac847e8a22099867586ae612025-08-20T02:23:36ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/686242686242Synthesis of Magnolignan, a New Pigment Lightening Component, via a Suzuki-Miyaura ReactionShuhei Narita0Tetsuhiro Ogura1Toyonobu Usuki2Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioicho, Chiyoda-ku, Tokyo 102-8554, JapanDepartment of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioicho, Chiyoda-ku, Tokyo 102-8554, JapanDepartment of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioicho, Chiyoda-ku, Tokyo 102-8554, JapanMagnolignan, 2,2′-dihydroxy-5,5′-dipropyl-biphenyl (1), is a down-regulator of melanin synthesis that inhibits the maturation of tyrosinase. In this study, a concise total synthesis of 1 was achieved in five steps with 50% overall yield starting from commercially available trans-anethole (2) via a Suzuki-Miyaura reaction.http://dx.doi.org/10.1155/2013/686242 |
| spellingShingle | Shuhei Narita Tetsuhiro Ogura Toyonobu Usuki Synthesis of Magnolignan, a New Pigment Lightening Component, via a Suzuki-Miyaura Reaction Journal of Chemistry |
| title | Synthesis of Magnolignan, a New Pigment Lightening Component, via a Suzuki-Miyaura Reaction |
| title_full | Synthesis of Magnolignan, a New Pigment Lightening Component, via a Suzuki-Miyaura Reaction |
| title_fullStr | Synthesis of Magnolignan, a New Pigment Lightening Component, via a Suzuki-Miyaura Reaction |
| title_full_unstemmed | Synthesis of Magnolignan, a New Pigment Lightening Component, via a Suzuki-Miyaura Reaction |
| title_short | Synthesis of Magnolignan, a New Pigment Lightening Component, via a Suzuki-Miyaura Reaction |
| title_sort | synthesis of magnolignan a new pigment lightening component via a suzuki miyaura reaction |
| url | http://dx.doi.org/10.1155/2013/686242 |
| work_keys_str_mv | AT shuheinarita synthesisofmagnolignananewpigmentlighteningcomponentviaasuzukimiyaurareaction AT tetsuhiroogura synthesisofmagnolignananewpigmentlighteningcomponentviaasuzukimiyaurareaction AT toyonobuusuki synthesisofmagnolignananewpigmentlighteningcomponentviaasuzukimiyaurareaction |