Multiple Approaches to Investigate the Transport and Activity-Dependent Release of BDNF and Their Application in Neurogenetic Disorders
Studies utilizing genetic and pharmacological manipulations in rodent models and neuronal cultures have revealed myriad roles of brain-derived neurotrophic factor (BDNF). Currently, this knowledge of BDNF function is being translated into improvement strategies for several debilitating neurological...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2012/203734 |
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| author | David Hartmann Jana Drummond Erik Handberg Sharday Ewell Lucas Pozzo-Miller |
| author_facet | David Hartmann Jana Drummond Erik Handberg Sharday Ewell Lucas Pozzo-Miller |
| author_sort | David Hartmann |
| collection | DOAJ |
| description | Studies utilizing genetic and pharmacological manipulations in rodent models and neuronal cultures have revealed myriad roles of brain-derived neurotrophic factor (BDNF). Currently, this knowledge of BDNF function is being translated into improvement strategies for several debilitating neurological disorders in which BDNF abnormalities play a prominent role. Common among the BDNF-related disorders are irregular trafficking and release of mature BDNF (mBDNF) and/or its prodomain predecessor, proBDNF. Thus, investigating the conditions required for proper trafficking and release of BDNF is an essential step toward understanding and potentially improving these neurological disorders. This paper will provide examples of disorders related to BDNF release and serve as a review of the techniques being used to study the trafficking and release of BDNF. |
| format | Article |
| id | doaj-art-b12cfc8843de495aaee8e44022340d53 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-b12cfc8843de495aaee8e44022340d532025-02-03T05:54:03ZengWileyNeural Plasticity2090-59041687-54432012-01-01201210.1155/2012/203734203734Multiple Approaches to Investigate the Transport and Activity-Dependent Release of BDNF and Their Application in Neurogenetic DisordersDavid Hartmann0Jana Drummond1Erik Handberg2Sharday Ewell3Lucas Pozzo-Miller4Department of Neurobiology, SHEL 1002, Civitan International Research Center, The University of Alabama at Birmingham, Birmingham, AL 35294-2182, USADepartment of Neurobiology, SHEL 1002, Civitan International Research Center, The University of Alabama at Birmingham, Birmingham, AL 35294-2182, USADepartment of Neurobiology, SHEL 1002, Civitan International Research Center, The University of Alabama at Birmingham, Birmingham, AL 35294-2182, USADepartment of Neurobiology, SHEL 1002, Civitan International Research Center, The University of Alabama at Birmingham, Birmingham, AL 35294-2182, USADepartment of Neurobiology, SHEL 1002, Civitan International Research Center, The University of Alabama at Birmingham, Birmingham, AL 35294-2182, USAStudies utilizing genetic and pharmacological manipulations in rodent models and neuronal cultures have revealed myriad roles of brain-derived neurotrophic factor (BDNF). Currently, this knowledge of BDNF function is being translated into improvement strategies for several debilitating neurological disorders in which BDNF abnormalities play a prominent role. Common among the BDNF-related disorders are irregular trafficking and release of mature BDNF (mBDNF) and/or its prodomain predecessor, proBDNF. Thus, investigating the conditions required for proper trafficking and release of BDNF is an essential step toward understanding and potentially improving these neurological disorders. This paper will provide examples of disorders related to BDNF release and serve as a review of the techniques being used to study the trafficking and release of BDNF.http://dx.doi.org/10.1155/2012/203734 |
| spellingShingle | David Hartmann Jana Drummond Erik Handberg Sharday Ewell Lucas Pozzo-Miller Multiple Approaches to Investigate the Transport and Activity-Dependent Release of BDNF and Their Application in Neurogenetic Disorders Neural Plasticity |
| title | Multiple Approaches to Investigate the Transport and Activity-Dependent Release of BDNF and Their Application in Neurogenetic Disorders |
| title_full | Multiple Approaches to Investigate the Transport and Activity-Dependent Release of BDNF and Their Application in Neurogenetic Disorders |
| title_fullStr | Multiple Approaches to Investigate the Transport and Activity-Dependent Release of BDNF and Their Application in Neurogenetic Disorders |
| title_full_unstemmed | Multiple Approaches to Investigate the Transport and Activity-Dependent Release of BDNF and Their Application in Neurogenetic Disorders |
| title_short | Multiple Approaches to Investigate the Transport and Activity-Dependent Release of BDNF and Their Application in Neurogenetic Disorders |
| title_sort | multiple approaches to investigate the transport and activity dependent release of bdnf and their application in neurogenetic disorders |
| url | http://dx.doi.org/10.1155/2012/203734 |
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