A Bio‐Responsive Hydrogel with Spatially Heterogeneous Structure for Treating Infectious Tissue Injuries
Abstract Infectious tissue injuries, exacerbated by bacterial infections and antibiotic resistance, pose significant challenges for treatment and may lead to life‐threatening systemic infections. In this study, a bio‐responsive hydrogel system is developed, leveraging silver ions (Ag⁺) encapsulated...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-06-01
|
| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202500088 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850115097099239424 |
|---|---|
| author | Zongtai Li Tao Yang Xiaolei Li Panchao Yin Bo Yang Dongying Li Yan Wang Wei Teng Qianqian Yu Weichang Li |
| author_facet | Zongtai Li Tao Yang Xiaolei Li Panchao Yin Bo Yang Dongying Li Yan Wang Wei Teng Qianqian Yu Weichang Li |
| author_sort | Zongtai Li |
| collection | DOAJ |
| description | Abstract Infectious tissue injuries, exacerbated by bacterial infections and antibiotic resistance, pose significant challenges for treatment and may lead to life‐threatening systemic infections. In this study, a bio‐responsive hydrogel system is developed, leveraging silver ions (Ag⁺) encapsulated in Preyssler‐type polyoxometalates (POMs). The Ag⁺ ions are selectively released in response to endogenous sodium ions (Na⁺) within the biological environment, enabling broad‐spectrum antibacterial activity. The POM serves as a protective matrix for Ag⁺, preserving its bioactivity while mitigating cytotoxicity and the reduction in antimicrobial efficacy associated with prolonged exposure. Additionally, a dual‐channel technique is employed to fabricate fiber membranes with controllable and continuously stacked chemical compositions, ensuring efficient and uniform POM incorporation via hydrogen bonding within the fiber matrix. Subsequently, in situ hierarchical cross‐linking process generated a spatially heterogeneous hydrogel with an interpenetrating network structure at multiple scales. This differentiated microstructure facilitates the controlled loading and release of diverse therapeutic components. Meanwhile, bioactive exosomes are integrated into the hydrogel, further enhancing its regenerative potential for treating infectious tissue injuries. In vitro and in vivo experiments demonstrated that the advanced hydrogel system provide a viable and efficient platform for addressing the challenges associated with infectious tissue injuries, offering a promising strategy for clinical applications. |
| format | Article |
| id | doaj-art-b125d2be710f4ff184049c67fe7d1055 |
| institution | OA Journals |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-b125d2be710f4ff184049c67fe7d10552025-08-20T02:36:40ZengWileyAdvanced Science2198-38442025-06-011223n/an/a10.1002/advs.202500088A Bio‐Responsive Hydrogel with Spatially Heterogeneous Structure for Treating Infectious Tissue InjuriesZongtai Li0Tao Yang1Xiaolei Li2Panchao Yin3Bo Yang4Dongying Li5Yan Wang6Wei Teng7Qianqian Yu8Weichang Li9Hospital of Stomatology Guangdong Provincial Key Laboratory of Stomatology Guanghua School of Stomatology Sun Yat‐sen University Guangzhou 510055 P. R. ChinaHospital of Stomatology Guangdong Provincial Key Laboratory of Stomatology Guanghua School of Stomatology Sun Yat‐sen University Guangzhou 510055 P. R. ChinaHospital of Stomatology Guangdong Provincial Key Laboratory of Stomatology Guanghua School of Stomatology Sun Yat‐sen University Guangzhou 510055 P. R. ChinaSouth China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft Matter Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of Technology Guangzhou 510640 P. R. ChinaHospital of Stomatology Guangdong Provincial Key Laboratory of Stomatology Guanghua School of Stomatology Sun Yat‐sen University Guangzhou 510055 P. R. ChinaHospital of Stomatology Guangdong Provincial Key Laboratory of Stomatology Guanghua School of Stomatology Sun Yat‐sen University Guangzhou 510055 P. R. ChinaHospital of Stomatology Guangdong Provincial Key Laboratory of Stomatology Guanghua School of Stomatology Sun Yat‐sen University Guangzhou 510055 P. R. ChinaHospital of Stomatology Guangdong Provincial Key Laboratory of Stomatology Guanghua School of Stomatology Sun Yat‐sen University Guangzhou 510055 P. R. ChinaSouth China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft Matter Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of Technology Guangzhou 510640 P. R. ChinaHospital of Stomatology Guangdong Provincial Key Laboratory of Stomatology Guanghua School of Stomatology Sun Yat‐sen University Guangzhou 510055 P. R. ChinaAbstract Infectious tissue injuries, exacerbated by bacterial infections and antibiotic resistance, pose significant challenges for treatment and may lead to life‐threatening systemic infections. In this study, a bio‐responsive hydrogel system is developed, leveraging silver ions (Ag⁺) encapsulated in Preyssler‐type polyoxometalates (POMs). The Ag⁺ ions are selectively released in response to endogenous sodium ions (Na⁺) within the biological environment, enabling broad‐spectrum antibacterial activity. The POM serves as a protective matrix for Ag⁺, preserving its bioactivity while mitigating cytotoxicity and the reduction in antimicrobial efficacy associated with prolonged exposure. Additionally, a dual‐channel technique is employed to fabricate fiber membranes with controllable and continuously stacked chemical compositions, ensuring efficient and uniform POM incorporation via hydrogen bonding within the fiber matrix. Subsequently, in situ hierarchical cross‐linking process generated a spatially heterogeneous hydrogel with an interpenetrating network structure at multiple scales. This differentiated microstructure facilitates the controlled loading and release of diverse therapeutic components. Meanwhile, bioactive exosomes are integrated into the hydrogel, further enhancing its regenerative potential for treating infectious tissue injuries. In vitro and in vivo experiments demonstrated that the advanced hydrogel system provide a viable and efficient platform for addressing the challenges associated with infectious tissue injuries, offering a promising strategy for clinical applications.https://doi.org/10.1002/advs.202500088bio‐responsivehydrogelinfectious tissue injuriespolyoxometalatesspatially heterogeneous |
| spellingShingle | Zongtai Li Tao Yang Xiaolei Li Panchao Yin Bo Yang Dongying Li Yan Wang Wei Teng Qianqian Yu Weichang Li A Bio‐Responsive Hydrogel with Spatially Heterogeneous Structure for Treating Infectious Tissue Injuries Advanced Science bio‐responsive hydrogel infectious tissue injuries polyoxometalates spatially heterogeneous |
| title | A Bio‐Responsive Hydrogel with Spatially Heterogeneous Structure for Treating Infectious Tissue Injuries |
| title_full | A Bio‐Responsive Hydrogel with Spatially Heterogeneous Structure for Treating Infectious Tissue Injuries |
| title_fullStr | A Bio‐Responsive Hydrogel with Spatially Heterogeneous Structure for Treating Infectious Tissue Injuries |
| title_full_unstemmed | A Bio‐Responsive Hydrogel with Spatially Heterogeneous Structure for Treating Infectious Tissue Injuries |
| title_short | A Bio‐Responsive Hydrogel with Spatially Heterogeneous Structure for Treating Infectious Tissue Injuries |
| title_sort | bio responsive hydrogel with spatially heterogeneous structure for treating infectious tissue injuries |
| topic | bio‐responsive hydrogel infectious tissue injuries polyoxometalates spatially heterogeneous |
| url | https://doi.org/10.1002/advs.202500088 |
| work_keys_str_mv | AT zongtaili abioresponsivehydrogelwithspatiallyheterogeneousstructurefortreatinginfectioustissueinjuries AT taoyang abioresponsivehydrogelwithspatiallyheterogeneousstructurefortreatinginfectioustissueinjuries AT xiaoleili abioresponsivehydrogelwithspatiallyheterogeneousstructurefortreatinginfectioustissueinjuries AT panchaoyin abioresponsivehydrogelwithspatiallyheterogeneousstructurefortreatinginfectioustissueinjuries AT boyang abioresponsivehydrogelwithspatiallyheterogeneousstructurefortreatinginfectioustissueinjuries AT dongyingli abioresponsivehydrogelwithspatiallyheterogeneousstructurefortreatinginfectioustissueinjuries AT yanwang abioresponsivehydrogelwithspatiallyheterogeneousstructurefortreatinginfectioustissueinjuries AT weiteng abioresponsivehydrogelwithspatiallyheterogeneousstructurefortreatinginfectioustissueinjuries AT qianqianyu abioresponsivehydrogelwithspatiallyheterogeneousstructurefortreatinginfectioustissueinjuries AT weichangli abioresponsivehydrogelwithspatiallyheterogeneousstructurefortreatinginfectioustissueinjuries AT zongtaili bioresponsivehydrogelwithspatiallyheterogeneousstructurefortreatinginfectioustissueinjuries AT taoyang bioresponsivehydrogelwithspatiallyheterogeneousstructurefortreatinginfectioustissueinjuries AT xiaoleili bioresponsivehydrogelwithspatiallyheterogeneousstructurefortreatinginfectioustissueinjuries AT panchaoyin bioresponsivehydrogelwithspatiallyheterogeneousstructurefortreatinginfectioustissueinjuries AT boyang bioresponsivehydrogelwithspatiallyheterogeneousstructurefortreatinginfectioustissueinjuries AT dongyingli bioresponsivehydrogelwithspatiallyheterogeneousstructurefortreatinginfectioustissueinjuries AT yanwang bioresponsivehydrogelwithspatiallyheterogeneousstructurefortreatinginfectioustissueinjuries AT weiteng bioresponsivehydrogelwithspatiallyheterogeneousstructurefortreatinginfectioustissueinjuries AT qianqianyu bioresponsivehydrogelwithspatiallyheterogeneousstructurefortreatinginfectioustissueinjuries AT weichangli bioresponsivehydrogelwithspatiallyheterogeneousstructurefortreatinginfectioustissueinjuries |