Impact of synthesized Zero-valance silver nanoparticles on acetylcholinesterase and xanthine oxidase: Toxicological and environmental implications
Nanoparticles have several applications in commercial and pharmaceutical products owing to their exceptional antibacterial characteristics. Nonetheless, the extensive creation of nanoparticles has significant concerns regarding their toxicological and environmental effects. Acetylcholinesterase (ACh...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Case Studies in Chemical and Environmental Engineering |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666016425000027 |
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| author | Srwa Hashim Mohammed Ahmed Mahdi Rheima Dhiey A. Al-aameri Haider Kamil Zaidan Zainab T. Al-Sharify |
| author_facet | Srwa Hashim Mohammed Ahmed Mahdi Rheima Dhiey A. Al-aameri Haider Kamil Zaidan Zainab T. Al-Sharify |
| author_sort | Srwa Hashim Mohammed |
| collection | DOAJ |
| description | Nanoparticles have several applications in commercial and pharmaceutical products owing to their exceptional antibacterial characteristics. Nonetheless, the extensive creation of nanoparticles has significant concerns regarding their toxicological and environmental effects. Acetylcholinesterase (AChE) and xanthine oxidase (XO) are important enzymes in neuroscience, toxicology, and pharmacology, which makes them good targets for studying how nanoparticles affect these areas. This study involved the synthesis of spherical silver nanoparticles (AgNPs) using ultraviolet (UV) irradiation and their subsequent characterization regarding structural and optical properties. The synthesizer technique utilized X-ray diffraction (XRD) and transmission electron microscopy (TEM) to ascertain the form and size of the nanoparticles, indicating an average diameter of approximately 20.23 nm. An enzymatic test evaluated the inhibitory effects of the synthesized Ag NPs on AChE and XO, using donepezil and allopurinol as positive controls. The results demonstrated that the Ag NPs displayed minimal enzyme inhibitory activity relative to the positive controls. This work underscores the necessity for additional research on the effects of nanoparticle interactions with essential biological systems. |
| format | Article |
| id | doaj-art-b1177030639840b58900577ba8e80eec |
| institution | Kabale University |
| issn | 2666-0164 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Case Studies in Chemical and Environmental Engineering |
| spelling | doaj-art-b1177030639840b58900577ba8e80eec2025-01-16T04:29:15ZengElsevierCase Studies in Chemical and Environmental Engineering2666-01642025-06-0111101095Impact of synthesized Zero-valance silver nanoparticles on acetylcholinesterase and xanthine oxidase: Toxicological and environmental implicationsSrwa Hashim Mohammed0Ahmed Mahdi Rheima1Dhiey A. Al-aameri2Haider Kamil Zaidan3Zainab T. Al-Sharify4Chemistry Department, College of Education, University of Garmian, Kalar, IraqDepartment of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq; Corresponding author.Mustansiriyah University، Quality Assurance and Performance Evaluation Department, Baghdad, IraqCollege of Nursing, Al- Mustaqbal University, 51001, Babil, IraqAl Hikma University College, Baghdad, Iraq; School of Chemical Engineering, University of Birmingham, Edgbaston, B15 2TT, Birmingham, United KingdomNanoparticles have several applications in commercial and pharmaceutical products owing to their exceptional antibacterial characteristics. Nonetheless, the extensive creation of nanoparticles has significant concerns regarding their toxicological and environmental effects. Acetylcholinesterase (AChE) and xanthine oxidase (XO) are important enzymes in neuroscience, toxicology, and pharmacology, which makes them good targets for studying how nanoparticles affect these areas. This study involved the synthesis of spherical silver nanoparticles (AgNPs) using ultraviolet (UV) irradiation and their subsequent characterization regarding structural and optical properties. The synthesizer technique utilized X-ray diffraction (XRD) and transmission electron microscopy (TEM) to ascertain the form and size of the nanoparticles, indicating an average diameter of approximately 20.23 nm. An enzymatic test evaluated the inhibitory effects of the synthesized Ag NPs on AChE and XO, using donepezil and allopurinol as positive controls. The results demonstrated that the Ag NPs displayed minimal enzyme inhibitory activity relative to the positive controls. This work underscores the necessity for additional research on the effects of nanoparticle interactions with essential biological systems.http://www.sciencedirect.com/science/article/pii/S2666016425000027NanoparticlesEnzyme inhibitionAChEIrradiation methodXanthine oxidase |
| spellingShingle | Srwa Hashim Mohammed Ahmed Mahdi Rheima Dhiey A. Al-aameri Haider Kamil Zaidan Zainab T. Al-Sharify Impact of synthesized Zero-valance silver nanoparticles on acetylcholinesterase and xanthine oxidase: Toxicological and environmental implications Case Studies in Chemical and Environmental Engineering Nanoparticles Enzyme inhibition AChE Irradiation method Xanthine oxidase |
| title | Impact of synthesized Zero-valance silver nanoparticles on acetylcholinesterase and xanthine oxidase: Toxicological and environmental implications |
| title_full | Impact of synthesized Zero-valance silver nanoparticles on acetylcholinesterase and xanthine oxidase: Toxicological and environmental implications |
| title_fullStr | Impact of synthesized Zero-valance silver nanoparticles on acetylcholinesterase and xanthine oxidase: Toxicological and environmental implications |
| title_full_unstemmed | Impact of synthesized Zero-valance silver nanoparticles on acetylcholinesterase and xanthine oxidase: Toxicological and environmental implications |
| title_short | Impact of synthesized Zero-valance silver nanoparticles on acetylcholinesterase and xanthine oxidase: Toxicological and environmental implications |
| title_sort | impact of synthesized zero valance silver nanoparticles on acetylcholinesterase and xanthine oxidase toxicological and environmental implications |
| topic | Nanoparticles Enzyme inhibition AChE Irradiation method Xanthine oxidase |
| url | http://www.sciencedirect.com/science/article/pii/S2666016425000027 |
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