THE STUDY OF THE INFLUENCE OF THE FLAVONOIDS ON ENERGY EXCHANGE MITOHONDRIALNYE PROTSESSY AND MICROSOMAL SYSTEMS IN THE LIVER IN ACUTE CCL4 - STEATOSIS IN RATS
In acute tetrachlorocarbon (CCl4) hepatotoxicity in experimental animals is developing a hypoxic condition in the liver, associated with the disruption of the mitochondrial respiratory chain and oxidative phosphorylation, increased anaerobiosis and development of energy deficiency. Disturbed detoxif...
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North-Caucasus Federal University
2022-10-01
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| Series: | Современная наука и инновации |
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| Online Access: | https://msi.elpub.ru/jour/article/view/1093 |
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| author | Elena Olegovna Sergeeva Elena Grigorievna Dorkina Lubov Anatolievna Sadjaia |
| author_facet | Elena Olegovna Sergeeva Elena Grigorievna Dorkina Lubov Anatolievna Sadjaia |
| author_sort | Elena Olegovna Sergeeva |
| collection | DOAJ |
| description | In acute tetrachlorocarbon (CCl4) hepatotoxicity in experimental animals is developing a hypoxic condition in the liver, associated with the disruption of the mitochondrial respiratory chain and oxidative phosphorylation, increased anaerobiosis and development of energy deficiency. Disturbed detoxification function of the liver, a reduction in the activity of glutathione-S-transferase and NADPH-dependent microsomal monooxygenase system, accompanied by compensatory increased activity of NADH is microsomal chain oxidation. The introduction of hesperidin, diosmin, flavizine and quercetin at doses of 100 mg/kg on General health scheme against Tetrachloromethane hepatosis in experimental animals prevents the development of hypoxia in the liver, improves the oxidative processes in mitochondria and aerobic production of energy, and increases the content of ATP in the liver. A complete recovery of NADH is the activity of the microsomes. |
| format | Article |
| id | doaj-art-b111c403952544118801198df4c9fd3e |
| institution | Kabale University |
| issn | 2307-910X |
| language | Russian |
| publishDate | 2022-10-01 |
| publisher | North-Caucasus Federal University |
| record_format | Article |
| series | Современная наука и инновации |
| spelling | doaj-art-b111c403952544118801198df4c9fd3e2025-08-20T03:42:18ZrusNorth-Caucasus Federal UniversityСовременная наука и инновации2307-910X2022-10-01021401461092THE STUDY OF THE INFLUENCE OF THE FLAVONOIDS ON ENERGY EXCHANGE MITOHONDRIALNYE PROTSESSY AND MICROSOMAL SYSTEMS IN THE LIVER IN ACUTE CCL4 - STEATOSIS IN RATSElena Olegovna Sergeeva0Elena Grigorievna Dorkina1Lubov Anatolievna Sadjaia2Ministry of Health VolgGMU Medical UniversityMinistry of Health VolgGMU Medical UniversityMinistry of Health VolgGMU Medical UniversityIn acute tetrachlorocarbon (CCl4) hepatotoxicity in experimental animals is developing a hypoxic condition in the liver, associated with the disruption of the mitochondrial respiratory chain and oxidative phosphorylation, increased anaerobiosis and development of energy deficiency. Disturbed detoxification function of the liver, a reduction in the activity of glutathione-S-transferase and NADPH-dependent microsomal monooxygenase system, accompanied by compensatory increased activity of NADH is microsomal chain oxidation. The introduction of hesperidin, diosmin, flavizine and quercetin at doses of 100 mg/kg on General health scheme against Tetrachloromethane hepatosis in experimental animals prevents the development of hypoxia in the liver, improves the oxidative processes in mitochondria and aerobic production of energy, and increases the content of ATP in the liver. A complete recovery of NADH is the activity of the microsomes.https://msi.elpub.ru/jour/article/view/1093флавоноидыгепатозащитное действиетоксическое поражение печенимитохондриальные процессымикросомальные ферментыflavonoidshepatoprotective effecttoxic liver damagemitochondrial processesmicrosomal enzymes |
| spellingShingle | Elena Olegovna Sergeeva Elena Grigorievna Dorkina Lubov Anatolievna Sadjaia THE STUDY OF THE INFLUENCE OF THE FLAVONOIDS ON ENERGY EXCHANGE MITOHONDRIALNYE PROTSESSY AND MICROSOMAL SYSTEMS IN THE LIVER IN ACUTE CCL4 - STEATOSIS IN RATS Современная наука и инновации флавоноиды гепатозащитное действие токсическое поражение печени митохондриальные процессы микросомальные ферменты flavonoids hepatoprotective effect toxic liver damage mitochondrial processes microsomal enzymes |
| title | THE STUDY OF THE INFLUENCE OF THE FLAVONOIDS ON ENERGY EXCHANGE MITOHONDRIALNYE PROTSESSY AND MICROSOMAL SYSTEMS IN THE LIVER IN ACUTE CCL4 - STEATOSIS IN RATS |
| title_full | THE STUDY OF THE INFLUENCE OF THE FLAVONOIDS ON ENERGY EXCHANGE MITOHONDRIALNYE PROTSESSY AND MICROSOMAL SYSTEMS IN THE LIVER IN ACUTE CCL4 - STEATOSIS IN RATS |
| title_fullStr | THE STUDY OF THE INFLUENCE OF THE FLAVONOIDS ON ENERGY EXCHANGE MITOHONDRIALNYE PROTSESSY AND MICROSOMAL SYSTEMS IN THE LIVER IN ACUTE CCL4 - STEATOSIS IN RATS |
| title_full_unstemmed | THE STUDY OF THE INFLUENCE OF THE FLAVONOIDS ON ENERGY EXCHANGE MITOHONDRIALNYE PROTSESSY AND MICROSOMAL SYSTEMS IN THE LIVER IN ACUTE CCL4 - STEATOSIS IN RATS |
| title_short | THE STUDY OF THE INFLUENCE OF THE FLAVONOIDS ON ENERGY EXCHANGE MITOHONDRIALNYE PROTSESSY AND MICROSOMAL SYSTEMS IN THE LIVER IN ACUTE CCL4 - STEATOSIS IN RATS |
| title_sort | study of the influence of the flavonoids on energy exchange mitohondrialnye protsessy and microsomal systems in the liver in acute ccl4 steatosis in rats |
| topic | флавоноиды гепатозащитное действие токсическое поражение печени митохондриальные процессы микросомальные ферменты flavonoids hepatoprotective effect toxic liver damage mitochondrial processes microsomal enzymes |
| url | https://msi.elpub.ru/jour/article/view/1093 |
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