Successful Treatment by Surgery and Lenvatinib of a Patient with Adrenal Metastasis of Papillary Thyroid Cancer
Papillary thyroid cancer (PTC) is considered an indolent cancer, but some PTC patients do present with distant metastases and treatment strategies for such patients are not well established. Recently, lenvatinib, an inhibitor of multiple tyrosine kinases, has been introduced to treat patients with a...
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2020/2107430 |
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| author | Hajime Nakamura Kohichi Takada Kazuyuki Murase Hiroki Sakamoto Naotaka Hayasaka Kazuma Ishikawa Yuki Ikeda Makoto Yoshida Satoshi Iyama Ko Kobayashi Tetsuya Shindo Shintaro Sugita Koji Miyanishi Masayoshi Kobune Naoya Masumori Junji Kato |
| author_facet | Hajime Nakamura Kohichi Takada Kazuyuki Murase Hiroki Sakamoto Naotaka Hayasaka Kazuma Ishikawa Yuki Ikeda Makoto Yoshida Satoshi Iyama Ko Kobayashi Tetsuya Shindo Shintaro Sugita Koji Miyanishi Masayoshi Kobune Naoya Masumori Junji Kato |
| author_sort | Hajime Nakamura |
| collection | DOAJ |
| description | Papillary thyroid cancer (PTC) is considered an indolent cancer, but some PTC patients do present with distant metastases and treatment strategies for such patients are not well established. Recently, lenvatinib, an inhibitor of multiple tyrosine kinases, has been introduced to treat patients with advanced PTC but carries a risk of serious adverse events such as hemorrhage. Here, we report a PTC patient with a left adrenal metastasis and lenvatinib-induced hemorrhage who underwent successful surgical resection and was subsequently treated with a lower dose of lenvatinib. The patient has now been in a stable state with no adverse events for nearly two years. This case highlights the importance of surgical resection of metastatic PTC and subsequent lenvatinib therapy, even when the tumor is at an advanced stage. |
| format | Article |
| id | doaj-art-b10ec97daeaf406d89c973aaec6b9894 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-b10ec97daeaf406d89c973aaec6b98942025-02-03T01:28:33ZengWileyCase Reports in Oncological Medicine2090-67062090-67142020-01-01202010.1155/2020/21074302107430Successful Treatment by Surgery and Lenvatinib of a Patient with Adrenal Metastasis of Papillary Thyroid CancerHajime Nakamura0Kohichi Takada1Kazuyuki Murase2Hiroki Sakamoto3Naotaka Hayasaka4Kazuma Ishikawa5Yuki Ikeda6Makoto Yoshida7Satoshi Iyama8Ko Kobayashi9Tetsuya Shindo10Shintaro Sugita11Koji Miyanishi12Masayoshi Kobune13Naoya Masumori14Junji Kato15Department of Medical Oncology, Sapporo Medical University School of Medicine, JapanDepartment of Medical Oncology, Sapporo Medical University School of Medicine, JapanDepartment of Medical Oncology, Sapporo Medical University School of Medicine, JapanDepartment of Medical Oncology, Sapporo Medical University School of Medicine, JapanDepartment of Medical Oncology, Sapporo Medical University School of Medicine, JapanDepartment of Medical Oncology, Sapporo Medical University School of Medicine, JapanDepartment of Medical Oncology, Sapporo Medical University School of Medicine, JapanDepartment of Medical Oncology, Sapporo Medical University School of Medicine, JapanDepartment of Hematology, Sapporo Medical University School of Medicine, JapanDepartment of Urology, Sapporo Medical University School of Medicine, JapanDepartment of Urology, Sapporo Medical University School of Medicine, JapanDepartment of Surgical Pathology, Sapporo Medical University School of Medicine, JapanDepartment of Medical Oncology, Sapporo Medical University School of Medicine, JapanDepartment of Hematology, Sapporo Medical University School of Medicine, JapanDepartment of Urology, Sapporo Medical University School of Medicine, JapanDepartment of Medical Oncology, Sapporo Medical University School of Medicine, JapanPapillary thyroid cancer (PTC) is considered an indolent cancer, but some PTC patients do present with distant metastases and treatment strategies for such patients are not well established. Recently, lenvatinib, an inhibitor of multiple tyrosine kinases, has been introduced to treat patients with advanced PTC but carries a risk of serious adverse events such as hemorrhage. Here, we report a PTC patient with a left adrenal metastasis and lenvatinib-induced hemorrhage who underwent successful surgical resection and was subsequently treated with a lower dose of lenvatinib. The patient has now been in a stable state with no adverse events for nearly two years. This case highlights the importance of surgical resection of metastatic PTC and subsequent lenvatinib therapy, even when the tumor is at an advanced stage.http://dx.doi.org/10.1155/2020/2107430 |
| spellingShingle | Hajime Nakamura Kohichi Takada Kazuyuki Murase Hiroki Sakamoto Naotaka Hayasaka Kazuma Ishikawa Yuki Ikeda Makoto Yoshida Satoshi Iyama Ko Kobayashi Tetsuya Shindo Shintaro Sugita Koji Miyanishi Masayoshi Kobune Naoya Masumori Junji Kato Successful Treatment by Surgery and Lenvatinib of a Patient with Adrenal Metastasis of Papillary Thyroid Cancer Case Reports in Oncological Medicine |
| title | Successful Treatment by Surgery and Lenvatinib of a Patient with Adrenal Metastasis of Papillary Thyroid Cancer |
| title_full | Successful Treatment by Surgery and Lenvatinib of a Patient with Adrenal Metastasis of Papillary Thyroid Cancer |
| title_fullStr | Successful Treatment by Surgery and Lenvatinib of a Patient with Adrenal Metastasis of Papillary Thyroid Cancer |
| title_full_unstemmed | Successful Treatment by Surgery and Lenvatinib of a Patient with Adrenal Metastasis of Papillary Thyroid Cancer |
| title_short | Successful Treatment by Surgery and Lenvatinib of a Patient with Adrenal Metastasis of Papillary Thyroid Cancer |
| title_sort | successful treatment by surgery and lenvatinib of a patient with adrenal metastasis of papillary thyroid cancer |
| url | http://dx.doi.org/10.1155/2020/2107430 |
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