Telocytes in inflammatory bowel diseases: contributions to pathology and therapeutic potentials
Telocytes, a novel mesenchymal cell population, are characterized by their distinctive long and slender projections known as telopodes and have garnered significant interest since their formal introduction to the literature in 2010. These cells have been identified in various tissues, including the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1452258/full |
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| _version_ | 1850098510893940736 |
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| author | Ronaldo Paolo Panganiban Christina McAninch Marina Chulkina Irina V. Pinchuk |
| author_facet | Ronaldo Paolo Panganiban Christina McAninch Marina Chulkina Irina V. Pinchuk |
| author_sort | Ronaldo Paolo Panganiban |
| collection | DOAJ |
| description | Telocytes, a novel mesenchymal cell population, are characterized by their distinctive long and slender projections known as telopodes and have garnered significant interest since their formal introduction to the literature in 2010. These cells have been identified in various tissues, including the gastrointestinal (GI) tract, where they are suggested to play important roles in maintaining structural integrity, immune modulation, and barrier function. Inflammatory bowel diseases (IBD), which include Crohn’s disease (CD) and ulcerative colitis (UC), are characterized by chronic inflammation and fibrosis. While limited information is available on the fate of telocytes in this group of diseases, it has been suggested that loss/plasticity of telocytes can be among the key factors contributing to their pathogenesis. This review focuses on the current understanding of telocytes, their structural features, and their distribution within the GI tract under gut homeostasis and IBD. We also discuss the roles of these cells in immune regulation and intestinal repair. We highlight evidence implicating telocytes in the pathogenesis of IBD and other chronic inflammatory diseases that share similar pathophysiological processes with IBD. Lastly, we discuss the current challenges in gut telocyte biology and the potential therapeutic implications of telocytes in IBD. |
| format | Article |
| id | doaj-art-b108a490a6434a079a030ddbcb06419f |
| institution | DOAJ |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-b108a490a6434a079a030ddbcb06419f2025-08-20T02:40:42ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-01-011210.3389/fcell.2024.14522581452258Telocytes in inflammatory bowel diseases: contributions to pathology and therapeutic potentialsRonaldo Paolo PanganibanChristina McAninchMarina ChulkinaIrina V. PinchukTelocytes, a novel mesenchymal cell population, are characterized by their distinctive long and slender projections known as telopodes and have garnered significant interest since their formal introduction to the literature in 2010. These cells have been identified in various tissues, including the gastrointestinal (GI) tract, where they are suggested to play important roles in maintaining structural integrity, immune modulation, and barrier function. Inflammatory bowel diseases (IBD), which include Crohn’s disease (CD) and ulcerative colitis (UC), are characterized by chronic inflammation and fibrosis. While limited information is available on the fate of telocytes in this group of diseases, it has been suggested that loss/plasticity of telocytes can be among the key factors contributing to their pathogenesis. This review focuses on the current understanding of telocytes, their structural features, and their distribution within the GI tract under gut homeostasis and IBD. We also discuss the roles of these cells in immune regulation and intestinal repair. We highlight evidence implicating telocytes in the pathogenesis of IBD and other chronic inflammatory diseases that share similar pathophysiological processes with IBD. Lastly, we discuss the current challenges in gut telocyte biology and the potential therapeutic implications of telocytes in IBD.https://www.frontiersin.org/articles/10.3389/fcell.2024.1452258/fulltelocytefibrosisIBDulcerative colitisCrohn’s disease |
| spellingShingle | Ronaldo Paolo Panganiban Christina McAninch Marina Chulkina Irina V. Pinchuk Telocytes in inflammatory bowel diseases: contributions to pathology and therapeutic potentials Frontiers in Cell and Developmental Biology telocyte fibrosis IBD ulcerative colitis Crohn’s disease |
| title | Telocytes in inflammatory bowel diseases: contributions to pathology and therapeutic potentials |
| title_full | Telocytes in inflammatory bowel diseases: contributions to pathology and therapeutic potentials |
| title_fullStr | Telocytes in inflammatory bowel diseases: contributions to pathology and therapeutic potentials |
| title_full_unstemmed | Telocytes in inflammatory bowel diseases: contributions to pathology and therapeutic potentials |
| title_short | Telocytes in inflammatory bowel diseases: contributions to pathology and therapeutic potentials |
| title_sort | telocytes in inflammatory bowel diseases contributions to pathology and therapeutic potentials |
| topic | telocyte fibrosis IBD ulcerative colitis Crohn’s disease |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2024.1452258/full |
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