Effect of Endotoxemia in Suckling Rats on Pancreatic Integrity and Exocrine Function in Adults: A Review Report
Background. Endotoxin (LPS), the component of Gram-negative bacteria, is responsible for sepsis and neonatal mortality, but low concentrations of LPS produced tissue protection in experimental studies. The effects of LPS applied to the suckling rats on the pancreas of adult animals have not been pre...
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2018-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2018/6915059 |
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| author | Jolanta Jaworek Barbara Tudek Paweł Kowalczyk Michalina Kot Joanna Szklarczyk Anna Leja-Szpak Piotr Pierzchalski Joanna Bonior Artur Dembiński Piotr Ceranowicz Zygmunt Warzecha Katarzyna Nawrot-Porąbka Krzysztof Gil |
| author_facet | Jolanta Jaworek Barbara Tudek Paweł Kowalczyk Michalina Kot Joanna Szklarczyk Anna Leja-Szpak Piotr Pierzchalski Joanna Bonior Artur Dembiński Piotr Ceranowicz Zygmunt Warzecha Katarzyna Nawrot-Porąbka Krzysztof Gil |
| author_sort | Jolanta Jaworek |
| collection | DOAJ |
| description | Background. Endotoxin (LPS), the component of Gram-negative bacteria, is responsible for sepsis and neonatal mortality, but low concentrations of LPS produced tissue protection in experimental studies. The effects of LPS applied to the suckling rats on the pancreas of adult animals have not been previously explored. We present the impact of neonatal endotoxemia on the pancreatic exocrine function and on the acute pancreatitis which has been investigated in the adult animals. Endotoxemia was induced in suckling rats by intraperitoneal application of LPS from Escherichia coli or Salmonella typhi. In the adult rats, pretreated in the early period of life with LPS, histological manifestations of acute pancreatitis have been reduced. Pancreatic weight and plasma lipase activity were decreased, and SOD concentration was reversed and accompanied by a significant reduction of lipid peroxidation products (MDA + 4 HNE) in the pancreatic tissue. In the pancreatic acini, the significant increases in protein signals for toll-like receptor 4 and for heat shock protein 60 were found. Signal for the CCK1 receptor was reduced and pancreatic secretory responses to caerulein were diminished, whereas basal enzyme secretion was unaffected. These pioneer studies have shown that exposition of suckling rats to endotoxin has an impact on the pancreas in the adult organism. |
| format | Article |
| id | doaj-art-b1081ab8386b4f979d1a869d88bba6dc |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-b1081ab8386b4f979d1a869d88bba6dc2025-02-03T01:02:31ZengWileyGastroenterology Research and Practice1687-61211687-630X2018-01-01201810.1155/2018/69150596915059Effect of Endotoxemia in Suckling Rats on Pancreatic Integrity and Exocrine Function in Adults: A Review ReportJolanta Jaworek0Barbara Tudek1Paweł Kowalczyk2Michalina Kot3Joanna Szklarczyk4Anna Leja-Szpak5Piotr Pierzchalski6Joanna Bonior7Artur Dembiński8Piotr Ceranowicz9Zygmunt Warzecha10Katarzyna Nawrot-Porąbka11Krzysztof Gil12Department of Medical Physiology, Faculty of Health Sciences, Jagiellonian University Medical College, 12 Michałowskiego Street, 31-126 Cracow, PolandInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, 5A Pawińskiego Street, 02-106 Warsaw, PolandDepartment of Animal Nutrition, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 3 Instytucka Street, 05-110 Jabłonna, PolandDepartment of Medical Physiology, Faculty of Health Sciences, Jagiellonian University Medical College, 12 Michałowskiego Street, 31-126 Cracow, PolandDepartment of Medical Physiology, Faculty of Health Sciences, Jagiellonian University Medical College, 12 Michałowskiego Street, 31-126 Cracow, PolandDepartment of Medical Physiology, Faculty of Health Sciences, Jagiellonian University Medical College, 12 Michałowskiego Street, 31-126 Cracow, PolandDepartment of Medical Physiology, Faculty of Health Sciences, Jagiellonian University Medical College, 12 Michałowskiego Street, 31-126 Cracow, PolandDepartment of Medical Physiology, Faculty of Health Sciences, Jagiellonian University Medical College, 12 Michałowskiego Street, 31-126 Cracow, PolandDepartment of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Cracow, PolandDepartment of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Cracow, PolandDepartment of Physiology, Faculty of Medicine, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Cracow, PolandDepartment of Medical Physiology, Faculty of Health Sciences, Jagiellonian University Medical College, 12 Michałowskiego Street, 31-126 Cracow, PolandDepartment of Pathophysiology, Faculty of Medical Sciences, Jagiellonian University Medical College, 18 Czysta Street, 31-121 Cracow, PolandBackground. Endotoxin (LPS), the component of Gram-negative bacteria, is responsible for sepsis and neonatal mortality, but low concentrations of LPS produced tissue protection in experimental studies. The effects of LPS applied to the suckling rats on the pancreas of adult animals have not been previously explored. We present the impact of neonatal endotoxemia on the pancreatic exocrine function and on the acute pancreatitis which has been investigated in the adult animals. Endotoxemia was induced in suckling rats by intraperitoneal application of LPS from Escherichia coli or Salmonella typhi. In the adult rats, pretreated in the early period of life with LPS, histological manifestations of acute pancreatitis have been reduced. Pancreatic weight and plasma lipase activity were decreased, and SOD concentration was reversed and accompanied by a significant reduction of lipid peroxidation products (MDA + 4 HNE) in the pancreatic tissue. In the pancreatic acini, the significant increases in protein signals for toll-like receptor 4 and for heat shock protein 60 were found. Signal for the CCK1 receptor was reduced and pancreatic secretory responses to caerulein were diminished, whereas basal enzyme secretion was unaffected. These pioneer studies have shown that exposition of suckling rats to endotoxin has an impact on the pancreas in the adult organism.http://dx.doi.org/10.1155/2018/6915059 |
| spellingShingle | Jolanta Jaworek Barbara Tudek Paweł Kowalczyk Michalina Kot Joanna Szklarczyk Anna Leja-Szpak Piotr Pierzchalski Joanna Bonior Artur Dembiński Piotr Ceranowicz Zygmunt Warzecha Katarzyna Nawrot-Porąbka Krzysztof Gil Effect of Endotoxemia in Suckling Rats on Pancreatic Integrity and Exocrine Function in Adults: A Review Report Gastroenterology Research and Practice |
| title | Effect of Endotoxemia in Suckling Rats on Pancreatic Integrity and Exocrine Function in Adults: A Review Report |
| title_full | Effect of Endotoxemia in Suckling Rats on Pancreatic Integrity and Exocrine Function in Adults: A Review Report |
| title_fullStr | Effect of Endotoxemia in Suckling Rats on Pancreatic Integrity and Exocrine Function in Adults: A Review Report |
| title_full_unstemmed | Effect of Endotoxemia in Suckling Rats on Pancreatic Integrity and Exocrine Function in Adults: A Review Report |
| title_short | Effect of Endotoxemia in Suckling Rats on Pancreatic Integrity and Exocrine Function in Adults: A Review Report |
| title_sort | effect of endotoxemia in suckling rats on pancreatic integrity and exocrine function in adults a review report |
| url | http://dx.doi.org/10.1155/2018/6915059 |
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