Myosin inhibition enhances cardiomyocyte cell cycle activity through SIRT1-NFAT-mediated H3K9me3 modification

Myosin inhibition enhances cardiomyocyte cell cycle activity through SIRT1-NFAT-mediated H3K9me3 modification

The limited regenerative capacity in adult mammalian heart is mainly attributed to the low cell cycle activity of cardiomyocytes. Achieving cardiomyocyte division is a challenging undertaking, as the contractile function, a major characteristic of cardiomyocytes, is not overall compatible with cell...

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Bibliographic Details
Main Authors: Rui Jiang, Jiayu Chen, Lijuan Pei, Shiqi Huang, Mengying Feng, Zhaohui Ouyang, Min Yuan, Yalin Zhu, Su Yao, Fenglian He, Hongjie Zhang, Xin Dong, Peng Xie, Ke Wei
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:European Journal of Cell Biology
Subjects:
SIRT1
NFAT
Cytoskeleton
H3K9me3
Cardiomyocyte cell cycle
Cardiomyocyte binucleation
Online Access:http://www.sciencedirect.com/science/article/pii/S0171933525000299
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