Deubiquitinase MYSM1 promotes doxorubicin-induced cardiotoxicity by mediating TRIM21-ferroptosis axis in cardiomyocytes

Deubiquitinase MYSM1 promotes doxorubicin-induced cardiotoxicity by mediating TRIM21-ferroptosis axis in cardiomyocytes

Abstract Anthracycline antitumor drug doxorubicin (DOX) induces severe cardiotoxicity. Deubiquitinating enzymes (DUBs) are crucial for protein stability and function and play a significant role in cardiac pathophysiology. By comparing RNA sequencing datasets and conducting functional screening, we d...

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Bibliographic Details
Main Authors: Xiaowen Shi, Jianjiang Xu, Xin Zhong, Yuanyuan Qian, Liming Lin, Zimin Fang, Bozhi Ye, Yiting Lyu, Ran Zhang, Zhanxiong Zheng, Jibo Han
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cell Communication and Signaling
Subjects:
Doxorubicin
Cardiotoxicity
Deubiquitinating enzymes
MYSM1
TRIM21
Ferroptosis
Online Access:https://doi.org/10.1186/s12964-024-01955-6
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