Interactions between glioblastoma and myeloid cells
Standing as the most aggressive form of primary malignant tumor, Glioblastoma (GBM) tumors with marked heterogeneity represents one of the enormous challenges in glioma treatment. Myeloid cells, which includes neutrophils, myeloid-derived suppressor cells, microglia, and macrophages, play a pivotal...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1632122/full |
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| author | Yuting Li Yuting Li Yuhong Chen Kai Cai Kai Cai Yujuan Qin Xi Wang Bo Zhang Lin Shi Zonglin He Zonglin He Jiasheng Wang Jiasheng Wang Jiecun Long Jiecun Long Yishun Zeng Yishun Zeng Qiong Gong Qiong Gong |
| author_facet | Yuting Li Yuting Li Yuhong Chen Kai Cai Kai Cai Yujuan Qin Xi Wang Bo Zhang Lin Shi Zonglin He Zonglin He Jiasheng Wang Jiasheng Wang Jiecun Long Jiecun Long Yishun Zeng Yishun Zeng Qiong Gong Qiong Gong |
| author_sort | Yuting Li |
| collection | DOAJ |
| description | Standing as the most aggressive form of primary malignant tumor, Glioblastoma (GBM) tumors with marked heterogeneity represents one of the enormous challenges in glioma treatment. Myeloid cells, which includes neutrophils, myeloid-derived suppressor cells, microglia, and macrophages, play a pivotal role in the tumor microenvironment of GBM. In the tumor microenvironment (TME), T cells and natural killer (NK) cells exert anti-tumor functions, whereas myeloid-derived suppressor cells (MDSCs) can promote tumor progression by suppressing these immune responses. Therefore, MDSCs play a critical role in shaping the effectiveness of immunotherapy. TME has constrained the ability of traditional GBM treatment approaches to significantly enhance prognostic outcomes for patients. This category encompasses conventional therapies like surgical resection and radiation therapy, along with cutting-edge methodologies such as immunotherapy. Through extensive investigations into the dynamic interactions between the GBM microenvironment and neoplastic cells, both targeted treatment strategies and innovative immunotherapeutic modalities have emerged, offering promising new directions for clinical intervention. This review focuses on the interactions between GBM and myeloid cells (MCs), providing novel insights into the oncogenesis and progression of GBM. |
| format | Article |
| id | doaj-art-b100496da15d46db98125fa7d97124e9 |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-b100496da15d46db98125fa7d97124e92025-08-20T03:30:08ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-06-011310.3389/fcell.2025.16321221632122Interactions between glioblastoma and myeloid cellsYuting Li0Yuting Li1Yuhong Chen2Kai Cai3Kai Cai4Yujuan Qin5Xi Wang6Bo Zhang7Lin Shi8Zonglin He9Zonglin He10Jiasheng Wang11Jiasheng Wang12Jiecun Long13Jiecun Long14Yishun Zeng15Yishun Zeng16Qiong Gong17Qiong Gong18Guangxi University of Chinese Medicine, Nanning, ChinaThe First Affiliated Hospital Of GuangxiUniversity Of Chinese Medicine, Nanning, ChinaDepartment of Nephrology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, ChinaGuangxi University of Chinese Medicine, Nanning, ChinaThe First Affiliated Hospital Of GuangxiUniversity Of Chinese Medicine, Nanning, ChinaInstitute of Cardiovascular Sciences, The People’s Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences, Nanning, ChinaSchool of Medicine, Guangxi University, Nanning, ChinaInstitute of Cardiovascular Sciences, The People’s Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences, Nanning, ChinaInstitute of Cardiovascular Sciences, The People’s Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences, Nanning, ChinaGuangxi University of Chinese Medicine, Nanning, ChinaThe First Affiliated Hospital Of GuangxiUniversity Of Chinese Medicine, Nanning, ChinaGuangxi University of Chinese Medicine, Nanning, ChinaThe First Affiliated Hospital Of GuangxiUniversity Of Chinese Medicine, Nanning, ChinaGuangxi University of Chinese Medicine, Nanning, ChinaThe First Affiliated Hospital Of GuangxiUniversity Of Chinese Medicine, Nanning, ChinaGuangxi University of Chinese Medicine, Nanning, ChinaThe First Affiliated Hospital Of GuangxiUniversity Of Chinese Medicine, Nanning, ChinaGuangxi University of Chinese Medicine, Nanning, ChinaThe First Affiliated Hospital Of GuangxiUniversity Of Chinese Medicine, Nanning, ChinaStanding as the most aggressive form of primary malignant tumor, Glioblastoma (GBM) tumors with marked heterogeneity represents one of the enormous challenges in glioma treatment. Myeloid cells, which includes neutrophils, myeloid-derived suppressor cells, microglia, and macrophages, play a pivotal role in the tumor microenvironment of GBM. In the tumor microenvironment (TME), T cells and natural killer (NK) cells exert anti-tumor functions, whereas myeloid-derived suppressor cells (MDSCs) can promote tumor progression by suppressing these immune responses. Therefore, MDSCs play a critical role in shaping the effectiveness of immunotherapy. TME has constrained the ability of traditional GBM treatment approaches to significantly enhance prognostic outcomes for patients. This category encompasses conventional therapies like surgical resection and radiation therapy, along with cutting-edge methodologies such as immunotherapy. Through extensive investigations into the dynamic interactions between the GBM microenvironment and neoplastic cells, both targeted treatment strategies and innovative immunotherapeutic modalities have emerged, offering promising new directions for clinical intervention. This review focuses on the interactions between GBM and myeloid cells (MCs), providing novel insights into the oncogenesis and progression of GBM.https://www.frontiersin.org/articles/10.3389/fcell.2025.1632122/fullGBMTAMMDSCTMEmyeloid cells |
| spellingShingle | Yuting Li Yuting Li Yuhong Chen Kai Cai Kai Cai Yujuan Qin Xi Wang Bo Zhang Lin Shi Zonglin He Zonglin He Jiasheng Wang Jiasheng Wang Jiecun Long Jiecun Long Yishun Zeng Yishun Zeng Qiong Gong Qiong Gong Interactions between glioblastoma and myeloid cells Frontiers in Cell and Developmental Biology GBM TAM MDSC TME myeloid cells |
| title | Interactions between glioblastoma and myeloid cells |
| title_full | Interactions between glioblastoma and myeloid cells |
| title_fullStr | Interactions between glioblastoma and myeloid cells |
| title_full_unstemmed | Interactions between glioblastoma and myeloid cells |
| title_short | Interactions between glioblastoma and myeloid cells |
| title_sort | interactions between glioblastoma and myeloid cells |
| topic | GBM TAM MDSC TME myeloid cells |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1632122/full |
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