Differential prognostic roles and clinical implications of mitochondrial and genomic tRNA-derived fragments in colorectal liver metastases

Abstract Background Colorectal liver metastases (CRLM) are the leading cause of colorectal cancer (CRC)-related mortality. Transfer RNA-derived fragments (tRFs), a novel class of small non-coding RNAs (sncRNA), regulate gene expression, stress response, and immune functions in cancer. While increasi...

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Main Authors:	Rebecca Zirnbauer, Daphni Ammon, Annalena Renner, Noam Hartman, Polina Kalinina, Patrick Starlinger, Stefan Stremitzer, Christoph Schwarz, Klaus Kaczirek, Michael Bergmann, Dietmar Pils, Johannes Laengle
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Series:	Journal of Translational Medicine
Subjects:	Colorectal liver metastases, CRLM Small RNA sequencing, sRNA-Seq tRNA-derived fragments, tRFs Mitochondrial tRNA-derived fragments, mt-tRFs Genomic tRNA-derived fragments, ge-tRFs
Online Access:	https://doi.org/10.1186/s12967-025-06850-3
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Differential prognostic roles and clinical implications of mitochondrial and genomic tRNA-derived fragments in colorectal liver metastases

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