Osteoprotegerin Polymorphisms in a Mexican Population with Rheumatoid Arthritis and Generalized Osteoporosis: A Preliminary Report
Bone disease in rheumatoid arthritis (RA) is a complex phenomenon where genetic risk factors have been partially evaluated. The system formed by receptor activator for nuclear factor-κB (RANK), receptor activator for nuclear factor-κB ligand (RANKL), and osteoprotegerin (OPG): RANK/RANKL/OPG is a cr...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/376197 |
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| author | Maria Guadalupe Zavala-Cerna Maria Cristina Moran-Moguel Jesus Alejandro Cornejo-Toledo Norma Guadalupe Gonzalez-Montoya Jose Sanchez-Corona Mario Salazar-Paramo Arnulfo Hernan Nava-Zavala Erika Anita Aguilar-Chavez Miriam Fabiola Alcaraz-Lopez Alicia Guadalupe Gonzalez-Sanchez Laura Gonzalez-Lopez Jorge Ivan Gamez-Nava |
| author_facet | Maria Guadalupe Zavala-Cerna Maria Cristina Moran-Moguel Jesus Alejandro Cornejo-Toledo Norma Guadalupe Gonzalez-Montoya Jose Sanchez-Corona Mario Salazar-Paramo Arnulfo Hernan Nava-Zavala Erika Anita Aguilar-Chavez Miriam Fabiola Alcaraz-Lopez Alicia Guadalupe Gonzalez-Sanchez Laura Gonzalez-Lopez Jorge Ivan Gamez-Nava |
| author_sort | Maria Guadalupe Zavala-Cerna |
| collection | DOAJ |
| description | Bone disease in rheumatoid arthritis (RA) is a complex phenomenon where genetic risk factors have been partially evaluated. The system formed by receptor activator for nuclear factor-κB (RANK), receptor activator for nuclear factor-κB ligand (RANKL), and osteoprotegerin (OPG): RANK/RANKL/OPG is a crucial molecular pathway for coupling between osteoblasts and osteoclasts, since OPG is able to inhibit osteoclast differentiation and activation. We aim to evaluate the association between SNPs C950T (rs2073617), C209T (rs3134069), T245G (rs3134070) in the TNFRSF11B (OPG) gene, and osteoporosis in RA. We included 81 women with RA and 52 healthy subjects in a cross-sectional study, genotyped them, and measured bone mineral density (BMD) at the lumbar spine and the femoral neck. Mean age in RA was 50±12 with disease duration of 12±8 years. According to BMD results, 23 (33.3%) were normal and 46 (66.7%) had osteopenia/osteoporosis. We found a higher prevalence of C allele for C950T SNP in RA. Polymorphisms C209T and T245G did not reach statistical significance in allele distribution. Further studies including patients from other regions of Latin America with a multicenter design to increase the sample size are required to confirm our findings and elucidate if C950T SNP could be associated with osteoporosis in RA. |
| format | Article |
| id | doaj-art-b0fcbb7cfbc34e288b10bcac486cd469 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-b0fcbb7cfbc34e288b10bcac486cd4692025-08-20T02:23:36ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/376197376197Osteoprotegerin Polymorphisms in a Mexican Population with Rheumatoid Arthritis and Generalized Osteoporosis: A Preliminary ReportMaria Guadalupe Zavala-Cerna0Maria Cristina Moran-Moguel1Jesus Alejandro Cornejo-Toledo2Norma Guadalupe Gonzalez-Montoya3Jose Sanchez-Corona4Mario Salazar-Paramo5Arnulfo Hernan Nava-Zavala6Erika Anita Aguilar-Chavez7Miriam Fabiola Alcaraz-Lopez8Alicia Guadalupe Gonzalez-Sanchez9Laura Gonzalez-Lopez10Jorge Ivan Gamez-Nava11Programa Internacional, Facultad de Medicina, Universidad Autonoma de Guadalajara, 44100 Zapopan, JAL, MexicoDivision de Medicina Molecular del Centro de Investigacion Biomedica de Occidente, Instituto Mexicano del Seguro Social, 44340 Guadalajara, JAL, MexicoDivision de Medicina Molecular del Centro de Investigacion Biomedica de Occidente, Instituto Mexicano del Seguro Social, 44340 Guadalajara, JAL, MexicoPrograma de Becarios en Investigacion del Instituto Mexicano del Seguro Social, Programa de Doctorado en Farmacologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 44340 Guadalajara, JAL, MexicoDivision de Medicina Molecular del Centro de Investigacion Biomedica de Occidente, Instituto Mexicano del Seguro Social, 44340 Guadalajara, JAL, MexicoDivision de Investigacion en Salud, UMAE, Hospital de Especialidades, CMNO, IMSS and Departamento de Fisiologia, CUCS, Universidad de Guadalajara, 44340 Guadalajara, JAL, MexicoPrograma Internacional, Facultad de Medicina, Universidad Autonoma de Guadalajara, 44100 Zapopan, JAL, MexicoUnidad de Medicina Familiar 2, Instituto Mexicano del Seguro Social, 44340 Guadalajara, JAL, MexicoDepartamento de Medicina Interna-Reumatologia, Hospital General de Zona 14, Instituto Mexicano del Seguro Social, 44860 Guadalajara, JAL, MexicoPrograma de Becarios en Investigacion del Instituto Mexicano del Seguro Social, Programa de Doctorado en Farmacologia, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 44340 Guadalajara, JAL, MexicoDepartamento de Medicina Interna-Reumatologia del Hospital General Regional No. 110, Instituto Mexicano del Seguro Social y Programa de Doctorado en Salud Publica, CUCS, Universidad de Guadalajara, 44340 Guadalajara, JAL, MexicoUnidad de Investigación en Epidemiologia Clinica, Hospital de Especialidades, Centro Medico Nacional de Occidente del Instituto Mexicano del Seguro Social y Programa de Doctorado en Salud Publica, CUCS, Universidad de Guadalajara, 44340 Guadalajara, JAL, MexicoBone disease in rheumatoid arthritis (RA) is a complex phenomenon where genetic risk factors have been partially evaluated. The system formed by receptor activator for nuclear factor-κB (RANK), receptor activator for nuclear factor-κB ligand (RANKL), and osteoprotegerin (OPG): RANK/RANKL/OPG is a crucial molecular pathway for coupling between osteoblasts and osteoclasts, since OPG is able to inhibit osteoclast differentiation and activation. We aim to evaluate the association between SNPs C950T (rs2073617), C209T (rs3134069), T245G (rs3134070) in the TNFRSF11B (OPG) gene, and osteoporosis in RA. We included 81 women with RA and 52 healthy subjects in a cross-sectional study, genotyped them, and measured bone mineral density (BMD) at the lumbar spine and the femoral neck. Mean age in RA was 50±12 with disease duration of 12±8 years. According to BMD results, 23 (33.3%) were normal and 46 (66.7%) had osteopenia/osteoporosis. We found a higher prevalence of C allele for C950T SNP in RA. Polymorphisms C209T and T245G did not reach statistical significance in allele distribution. Further studies including patients from other regions of Latin America with a multicenter design to increase the sample size are required to confirm our findings and elucidate if C950T SNP could be associated with osteoporosis in RA.http://dx.doi.org/10.1155/2015/376197 |
| spellingShingle | Maria Guadalupe Zavala-Cerna Maria Cristina Moran-Moguel Jesus Alejandro Cornejo-Toledo Norma Guadalupe Gonzalez-Montoya Jose Sanchez-Corona Mario Salazar-Paramo Arnulfo Hernan Nava-Zavala Erika Anita Aguilar-Chavez Miriam Fabiola Alcaraz-Lopez Alicia Guadalupe Gonzalez-Sanchez Laura Gonzalez-Lopez Jorge Ivan Gamez-Nava Osteoprotegerin Polymorphisms in a Mexican Population with Rheumatoid Arthritis and Generalized Osteoporosis: A Preliminary Report Journal of Immunology Research |
| title | Osteoprotegerin Polymorphisms in a Mexican Population with Rheumatoid Arthritis and Generalized Osteoporosis: A Preliminary Report |
| title_full | Osteoprotegerin Polymorphisms in a Mexican Population with Rheumatoid Arthritis and Generalized Osteoporosis: A Preliminary Report |
| title_fullStr | Osteoprotegerin Polymorphisms in a Mexican Population with Rheumatoid Arthritis and Generalized Osteoporosis: A Preliminary Report |
| title_full_unstemmed | Osteoprotegerin Polymorphisms in a Mexican Population with Rheumatoid Arthritis and Generalized Osteoporosis: A Preliminary Report |
| title_short | Osteoprotegerin Polymorphisms in a Mexican Population with Rheumatoid Arthritis and Generalized Osteoporosis: A Preliminary Report |
| title_sort | osteoprotegerin polymorphisms in a mexican population with rheumatoid arthritis and generalized osteoporosis a preliminary report |
| url | http://dx.doi.org/10.1155/2015/376197 |
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