A Case Report of Hypothyrotropin Hypothyroidism Caused by Roxadustat
Roxadustat is the world's first small molecule hypoxia-inducible factor prolyl hydroxylase inhibitor. Its adverse effect of causing hypothyroidism with low thyroid-stimulating hormone (TSH) is relatively rare and manifests subtly in elderly patients with multiple coexisting diseases. This artic...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Medical Journal of Peking Union Medical College Hospital
2025-03-01
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| Series: | Xiehe Yixue Zazhi |
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| Online Access: | https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-0115 |
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| author | YAN Xuelian TANG Bingying QU Xuan ZHANG Ning KANG Lin |
| author_facet | YAN Xuelian TANG Bingying QU Xuan ZHANG Ning KANG Lin |
| author_sort | YAN Xuelian |
| collection | DOAJ |
| description | Roxadustat is the world's first small molecule hypoxia-inducible factor prolyl hydroxylase inhibitor. Its adverse effect of causing hypothyroidism with low thyroid-stimulating hormone (TSH) is relatively rare and manifests subtly in elderly patients with multiple coexisting diseases. This article reports a case of an elderly patient with renal anemia who developed reversible low-TSH hypothyroidism after taking roxadustat for 12 days, with a significant decrease in thyroid hormone levels. After discontinuing roxadustat for 15 days, the thyroid hormone levels gradually returned to normal. Due to the worsening of renal anemia, the patient took roxadustat again, and 9 days later, the thyroid function-related indicators decreased upon re-examination, leading to the initiation of levothyroxine replacement therapy. In conjunction with relevant literature, this article analyzes the adverse reactions that occur during the oral administration of roxadustat in elderly patients with chronic kidney disease, aiming to provide reference for drug treatment of such patients. |
| format | Article |
| id | doaj-art-b0f8d1bbdc8a45fdb117e693bd707c32 |
| institution | OA Journals |
| issn | 1674-9081 |
| language | zho |
| publishDate | 2025-03-01 |
| publisher | Editorial Office of Medical Journal of Peking Union Medical College Hospital |
| record_format | Article |
| series | Xiehe Yixue Zazhi |
| spelling | doaj-art-b0f8d1bbdc8a45fdb117e693bd707c322025-08-20T02:16:05ZzhoEditorial Office of Medical Journal of Peking Union Medical College HospitalXiehe Yixue Zazhi1674-90812025-03-0116251952210.12290/xhyxzz.2024-0115A Case Report of Hypothyrotropin Hypothyroidism Caused by RoxadustatYAN Xuelian0TANG Bingying1QU Xuan2ZHANG Ning3KANG Lin4Department of Pharmacy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Pharmacy, Yantai Yuhuangding Hospital, Yantai, Shandong 264009, ChinaDepartment of Geriatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Geriatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Geriatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaRoxadustat is the world's first small molecule hypoxia-inducible factor prolyl hydroxylase inhibitor. Its adverse effect of causing hypothyroidism with low thyroid-stimulating hormone (TSH) is relatively rare and manifests subtly in elderly patients with multiple coexisting diseases. This article reports a case of an elderly patient with renal anemia who developed reversible low-TSH hypothyroidism after taking roxadustat for 12 days, with a significant decrease in thyroid hormone levels. After discontinuing roxadustat for 15 days, the thyroid hormone levels gradually returned to normal. Due to the worsening of renal anemia, the patient took roxadustat again, and 9 days later, the thyroid function-related indicators decreased upon re-examination, leading to the initiation of levothyroxine replacement therapy. In conjunction with relevant literature, this article analyzes the adverse reactions that occur during the oral administration of roxadustat in elderly patients with chronic kidney disease, aiming to provide reference for drug treatment of such patients.https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-0115roxadustathypoxia-inducible factor-prolyl hydroxylase inhibitorshypothyrotropin hypothyroidism |
| spellingShingle | YAN Xuelian TANG Bingying QU Xuan ZHANG Ning KANG Lin A Case Report of Hypothyrotropin Hypothyroidism Caused by Roxadustat Xiehe Yixue Zazhi roxadustat hypoxia-inducible factor-prolyl hydroxylase inhibitors hypothyrotropin hypothyroidism |
| title | A Case Report of Hypothyrotropin Hypothyroidism Caused by Roxadustat |
| title_full | A Case Report of Hypothyrotropin Hypothyroidism Caused by Roxadustat |
| title_fullStr | A Case Report of Hypothyrotropin Hypothyroidism Caused by Roxadustat |
| title_full_unstemmed | A Case Report of Hypothyrotropin Hypothyroidism Caused by Roxadustat |
| title_short | A Case Report of Hypothyrotropin Hypothyroidism Caused by Roxadustat |
| title_sort | case report of hypothyrotropin hypothyroidism caused by roxadustat |
| topic | roxadustat hypoxia-inducible factor-prolyl hydroxylase inhibitors hypothyrotropin hypothyroidism |
| url | https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-0115 |
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